CAS 2126789-08-8

N-Acetyl-N-[2-(4-bromobenzoyl)phenyl]-2-chloroacetamide

Codes: Bromfenac Sodium-025

Application context (from source-drug indications)

Inflammatory diseaseBromfenac SodiumPostoperative painBromfenac Sodium眼睛发炎Bromfenac Sodium眼睛疼痛Bromfenac SodiumDry eye syndromeBromfenac Sodium黄斑水肿Bromfenac Sodium

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Bromfenac Sodium	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Bromfenac SodiumOptimised routesteps: 4total yield: 257.8g(Bromfenac Sodium (API))

2-Amino-4'-bromobenzophenone→N-[2-(4-Bromobenzoyl)phenyl]acetamide→2-Bromoacetyl bromide→2-Chloroacetyl chloride→Bromoacetic anhydride→Chloroacetic anhydride→N-Acetyl-2-bromo-N-[2-(4-bromobenzoyl)phenyl]acetamide→N-Acetyl-N-[2-(4-bromobenzoyl)phenyl]-2-chloroacetamide→1-Acetyl-7-(4-bromobenzoyl)-1,3-dihydro-2H-indol-2-one

Intermediates available on this site

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