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CAS 2162-31-4

2-((tetrahydro-2H-pyran-2-yl)oxy)ethan-1-ol

Codes: BOSE-010

Application context (from source-drug indications)

溃疡Bosentan HydratePulmonary arterial hypertensionBosentan HydratePulmonary hypertensionBosentan HydrateSystemic sclerosisBosentan Hydrate冠状血管痉挛Bosentan Hydrate大动脉炎Bosentan Hydrate

Source drugs (routes using this intermediate)

DrugTierExpiry
Bosentan HydrateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Bosentan HydrateOptimised routesteps: 3total yield: 107 mg
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine→4-(tert-butyl)benzenesulfonamide→2-((tetrahydro-2H-pyran-2-yl)oxy)ethan-1-ol→4-chloro-5-(2-methoxyphenoxy)-6-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)-2,2'-bipyrimidine→4-(tert-butyl)-N-(5-(2-methoxyphenoxy)-6-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide

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