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CAS 219680-63-4

(E)-tert-butyl 8-(methoxyimino)-2,6-diazaspiro[3.4]octane-2-carboxylate

Codes:ZABO-011

Application context (from source-drug indications)

慢性阻塞性肺疾病Zabofloxacin Hydrochloride社区获得性肺炎Zabofloxacin Hydrochloride

Source drugs (routes using this intermediate)

DrugTierExpiry
Zabofloxacin HydrochlorideZabofloxacin HydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Zabofloxacin Hydrochloride原研路线steps: 12total yield: 220.00 mg
1-benzyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate→1-benzyl 3-ethyl 3-(hydroxymethyl)-4-oxopyrrolidine-1,3-dicarboxylate→(Z)-1-benzyl 3-ethyl 3-(hydroxymethyl)-4-(methoxyimino)pyrrolidine-1,3-dicarboxylate→(Z)-1-benzyl 3-ethyl 4-(methoxyimino)-3-(((methylsulfonyl)oxy)methyl)pyrrolidine-1,3-dicarboxylate→(E)-benzyl 3-(hydroxymethyl)-4-(methoxyimino)-3-(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate→(E)-benzyl 3-(azidomethyl)-3-(hydroxymethyl)-4-(methoxyimino)pyrrolidine-1-carboxylate→(E)-benzyl 3-(azidomethyl)-4-(methoxyimino)-3-(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate→(E)-benzyl 3-(aminomethyl)-4-(methoxyimino)-3-(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate→(E)-benzyl 8-(methoxyimino)-2,6-diazaspiro[3.4]octane-6-carboxylate→(E)-6-benzyl 2-tert-butyl 8-(methoxyimino)-2,6-diazaspiro[3.4]octane-2,6-dicarboxylate→(E)-tert-butyl 8-(methoxyimino)-2,6-diazaspiro[3.4]octane-2-carboxylate→7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid→(E)-7-(2-(tert-butoxycarbonyl)-8-(methoxyimino)-2,6-diazaspiro[3.4]octan-6-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.