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CAS 227954-90-7
1-oxo-1,3-dihydroisobenzofuran-5-carbonyl chloride
Codes: ESCI-009
Application context (from source-drug indications)
社交恐惧症Escitalopram OxalateMajor depressive disorderEscitalopram OxalatePanic disorderEscitalopram OxalateDepressionEscitalopram OxalateAnxiety disorderEscitalopram OxalateIrritable bowel syndromeEscitalopram Oxalate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Escitalopram Oxalate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-oxo-1,3-dihydroisobenzofuran-5-carboxylic acid→1-oxo-1,3-dihydroisobenzofuran-5-carbonyl chloride→2-amino-2-methylpropan-1-ol→N-(1-hydroxy-2-methylpropan-2-yl)-1-oxo-1,3-dihydroisobenzofuran-5-carboxamide→5-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)isobenzofuran-1(3H)-one→(4-fluorophenyl)magnesium bromide→(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-2-(hydroxymethyl)phenyl)(4-fluorophenyl)methanone→(3-(dimethylamino)propyl)magnesium chloride→1-(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-2-(hydroxymethyl)phenyl)-4-(dimethylamino)-1-(4-fluorophenyl)butan-1-ol→(S)-1-(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-2-(hydroxymethyl)phenyl)-4-(dimethylamino)-1-(4-fluorophenyl)butan-1-ol→(S)-3-(5-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine
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