Escitalopram Oxalate

Tier C — Watch / trade

Originator

2002

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：SERT

Brand：Lexapro, Esertia, Entact, Cipralex, Gaudium, Seroplex

Indications (approved)：社交恐惧症, Major depressive disorder, Panic disorder, Depression, Anxiety disorder

Regional status

Approved

2002-08-14

Discontinued

2009-02-01

China

Approved

2005-08-31

Japan

Approved

2011-04-22

Factories producing this API2

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

2 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 4 · Total yield 0.6 g

ESCI-00182104-74-3ESCI-002460-00-4ESCI-003865538-53-0ESCI-004109-54-6ESCI-0051310685-68-7ESCI-006103146-25-4ESCI-00720445-31-2API · Escitalopram Oxalate

Code	CAS No.	Intermediate
ESCI-001	82104-74-3	1-oxo-1,3-dihydroisobenzofuran-5-carbonitrile
ESCI-002	460-00-4	1-bromo-4-fluorobenzene
ESCI-003	865538-53-0	magnesium (5-cyano-2-(4-fluorobenzoyl)phenyl)methanolate bromide
ESCI-004	109-54-6	3-chloro-N,N-dimethylpropan-1-amine
ESCI-005	1310685-68-7	magnesium 1-(4-cyano-2-(oxidomethyl)phenyl)-4-(dimethylamino)-1-(4-fluorophenyl)butan-1-olate bromide chloride
ESCI-006	103146-25-4	4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile
ESCI-007	20445-31-2	(R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid

OptimisedRoute 2Steps 8 · Total yield /

ESCI-0084792-29-4ESCI-009227954-90-7ESCI-010124-68-5ESCI-011227954-82-7ESCI-012265137-37-9ESCI-013352-13-6ESCI-014—ESCI-015154034-91-0ESCI-016265137-38-0ESCI-017—ESCI-018—API · Escitalopram Oxalate

Code	CAS No.	Intermediate
ESCI-008	4792-29-4	1-oxo-1,3-dihydroisobenzofuran-5-carboxylic acid
ESCI-009	227954-90-7	1-oxo-1,3-dihydroisobenzofuran-5-carbonyl chloride
ESCI-010	124-68-5 Available	2-amino-2-methylpropan-1-ol
ESCI-011	227954-82-7	N-(1-hydroxy-2-methylpropan-2-yl)-1-oxo-1,3-dihydroisobenzofuran-5-carboxamide
ESCI-012	265137-37-9	5-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)isobenzofuran-1(3H)-one
ESCI-013	352-13-6 Available	(4-fluorophenyl)magnesium bromide
ESCI-014	-	(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-2-(hydroxymethyl)phenyl)(4-fluorophenyl)methanone
ESCI-015	154034-91-0	(3-(dimethylamino)propyl)magnesium chloride
ESCI-016	265137-38-0	1-(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-2-(hydroxymethyl)phenyl)-4-(dimethylamino)-1-(4-fluorophenyl)butan-1-ol
ESCI-017	-	(S)-1-(4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-2-(hydroxymethyl)phenyl)-4-(dimethylamino)-1-(4-fluorophenyl)butan-1-ol
ESCI-018	-	(S)-3-(5-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine

OptimisedRoute 3Steps 9 · Total yield 7.6 mg

ESCI-01935161-71-8ESCI-020124045-51-8ESCI-021459-57-4ESCI-0221352344-86-5ESCI-0231352344-87-6ESCI-02419009-39-3ESCI-0251352344-88-7ESCI-026848953-05-9ESCI-0271352344-89-8ESCI-0281352344-93-4ESCI-029144025-14-9ESCI-03041963-20-6API · Escitalopram Oxalate

Code	CAS No.	Intermediate
ESCI-019	35161-71-8	N-methylprop-2-yn-1-amine
ESCI-020	124045-51-8	tert-butyl methyl(prop-2-yn-1-yl)carbamate
ESCI-021	459-57-4	4-fluorobenzaldehyde
ESCI-022	1352344-86-5	tert-butyl (R)-(4-(4-fluorophenyl)-4-hydroxybut-2-yn-1-yl)(methyl)carbamate
ESCI-023	1352344-87-6	tert-butyl (S)-(4-(4-fluorophenyl)-4-hydroxybutyl)(methyl)carbamate
ESCI-024	19009-39-3	diisopropylcarbamic chloride
ESCI-025	1352344-88-7	(S)-4-((tert-butoxycarbonyl)(methyl)amino)-1-(4-fluorophenyl)butyl diisopropylcarbamate
ESCI-026	848953-05-9	3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
ESCI-027	1352344-89-8	tert-butyl (S)-(4-(4-cyano-2-methylphenyl)-4-(4-fluorophenyl)-4-hydroxybutyl)(methyl)carbamate
ESCI-028	1352344-93-4	tert-butyl (S)-(3-(5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)propyl)(methyl)carbamate
ESCI-029	144025-14-9	(S)-1-(4-fluorophenyl)-1-(3-(methylamino)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile
ESCI-030	41963-20-6	4-bromo-3-methylbenzonitrile

OptimisedRoute 4Steps 6 · Total yield 18 g

ESCI-004109-54-6ESCI-03141284-92-8ESCI-032—ESCI-033—ESCI-034—ESCI-035—ESCI-036878655-30-2ESCI-002460-00-4API · Escitalopram Oxalate

Code	CAS No.	Intermediate
ESCI-004	109-54-6	3-chloro-N,N-dimethylpropan-1-amine
ESCI-031	41284-92-8	5-iodoisobenzofuran-1(3H)-one
ESCI-032	-	magnesium (2-(4-fluorobenzoyl)-5-iodophenyl)methanolate bromide
ESCI-033	-	magnesium 4-(dimethylamino)-1-(4-fluorophenyl)-1-(4-iodo-2-(oxidomethyl)phenyl)butan-1-olate bromide chloride
ESCI-034	-	4-(dimethylamino)-1-(4-fluorophenyl)-1-(2-(hydroxymethyl)-4-iodophenyl)butan-1-ol
ESCI-035	-	(S)-4-(dimethylamino)-1-(4-fluorophenyl)-1-(2-(hydroxymethyl)-4-iodophenyl)butan-1-ol
ESCI-036	878655-30-2	(S)-3-(1-(4-fluorophenyl)-5-iodo-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine
ESCI-002	460-00-4	1-bromo-4-fluorobenzene

OptimisedRoute 5Steps 8 · Total yield /

ESCI-0251352344-88-7ESCI-029144025-14-9ESCI-03041963-20-6ESCI-037190197-86-5ESCI-038254744-14-4ESCI-039905710-66-9ESCI-0401352344-84-3ESCI-0411352344-85-4ESCI-0421352344-90-1API · Escitalopram Oxalate

Code	CAS No.	Intermediate
ESCI-025	1352344-88-7	(S)-4-((tert-butoxycarbonyl)(methyl)amino)-1-(4-fluorophenyl)butyl diisopropylcarbamate
ESCI-029	144025-14-9	(S)-1-(4-fluorophenyl)-1-(3-(methylamino)propyl)-1,3-dihydroisobenzofuran-5-carbonitrile
ESCI-030	41963-20-6	4-bromo-3-methylbenzonitrile
ESCI-037	190197-86-5	4-bromo-3-(bromomethyl)benzonitrile
ESCI-038	254744-14-4	2-bromo-5-cyanobenzyl acetate
ESCI-039	905710-66-9	4-bromo-3-(hydroxymethyl)benzonitrile
ESCI-040	1352344-84-3	4-bromo-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)benzonitrile
ESCI-041	1352344-85-4	3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
ESCI-042	1352344-90-1	tert-butyl ((4S)-4-(4-cyano-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenyl)-4-(4-fluorophenyl)-4-hydroxybutyl)(methyl)carbamate

Frequently asked questions

What are the approved indications of Escitalopram Oxalate?

Approved indications include: 社交恐惧症, Major depressive disorder, Panic disorder, Depression, Anxiety disorder.

When does the Escitalopram Oxalate patent expire?

No public expiry year is available for Escitalopram Oxalate yet; this page updates once verified.

How many synthesis routes are recorded for Escitalopram Oxalate?

5 synthesis routes are recorded; the shortest is 4 steps with 0.6 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Escitalopram Oxalate intermediates?

2 intermediate CAS of Escitalopram Oxalate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Escitalopram Oxalate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-27