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CAS 256376-59-7
ethyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylate
Codes：RIOC-005
Application context (from source-drug indications)
肺动脉高压利奥西呱肺性高血压利奥西呱慢性血栓栓塞性肺高压利奥西呱血栓形成利奥西呱左心室功能不全利奥西呱特发性肺动脉高压利奥西呱
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 利奥西呱Riociguat | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(2-fluorobenzyl)hydrazine→sodium (Z)-1-cyano-3-ethoxy-3-oxoprop-1-en-2-olate→ethyl 5-amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate→(E)-3-(dimethylamino)acrylaldehyde→ethyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylate→1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide→1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile→1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide→(E)-2-(phenyldiazenyl)malononitrile→(E)-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-5-(phenyldiazenyl)pyrimidine-4,6-diamine→2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine→methyl carbonochloridate→methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate
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