利奥西呱
Tier B — Position earlyRiociguat
Targets：sGC
Brand：安吉奥、Adempas
Indications (approved)：肺动脉高压、肺性高血压、慢性血栓栓塞性肺高压
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| RIOC-001 | 51859-98-4 | (2-fluorobenzyl)hydrazine |
| RIOC-002 | - | sodium (Z)-1-cyano-3-ethoxy-3-oxoprop-1-en-2-olate |
| RIOC-003 | 256504-39-9 | ethyl 5-amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate |
| RIOC-004 | 927-63-9 | (E)-3-(dimethylamino)acrylaldehyde |
| RIOC-005 | 256376-59-7 | ethyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylate |
| RIOC-006 | 256376-62-2 | 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide |
| RIOC-007 | 256376-65-5 | 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile |
| RIOC-008 | 256376-68-8 | 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide |
| RIOC-009 | - | (E)-2-(phenyldiazenyl)malononitrile |
| RIOC-010 | 370879-49-5 | (E)-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-5-(phenyldiazenyl)pyrimidine-4,6-diamine |
| RIOC-011 | 428854-24-4 | 2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine |
| RIOC-012 | 79-22-1 | methyl carbonochloridate |
| RIOC-013 | - | methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate |
Frequently asked questions
What are the approved indications of Riociguat?
Approved indications include: 肺动脉高压, 肺性高血压, 慢性血栓栓塞性肺高压.
When does the Riociguat patent expire?
No public expiry year is available for Riociguat yet; this page updates once verified.
How many synthesis routes are recorded for Riociguat?
1 synthesis routes are recorded; the shortest is 9 steps with 14.9 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Riociguat intermediates?
All intermediates in Riociguat routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Riociguat intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24