CAS 26272-90-2

hexadecyl carbonochloridate

Codes：CETI-002

Application context (from source-drug indications)

肥胖症赛利司他二型糖尿病赛利司他

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
赛利司他Cetilistat	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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赛利司他原研路线steps: 2total yield: 2.51 g

hexadecan-1-ol→hexadecyl carbonochloridate→2-amino-5-methylbenzoic acid

赛利司他优化路线steps: 4total yield: 18.5 g

hexadecyl carbonochloridate→2-amino-5-methylbenzoic acid→2-(((hexadecyloxy)carbonyl)amino)-5-methylbenzoic acid→methyl 2-amino-5-methylbenzoate sulfate→methyl 2-(((hexadecyloxy)carbonyl)amino)-5-methylbenzoate

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