← Back to patent-cliff list
CAS 26839-75-8
(S)-1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
Codes：Timolol Maleate-005
Application context (from source-drug indications)
高眼压酒石酸溴莫尼定/马来酸噻吗洛尔青光眼酒石酸溴莫尼定/马来酸噻吗洛尔高眼压贝美前列素/马来酸噻吗洛尔开角型青光眼贝美前列素/马来酸噻吗洛尔青光眼贝美前列素/马来酸噻吗洛尔
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 酒石酸溴莫尼定/马来酸噻吗洛尔Brimonidine Tartrate/Timolol Maleate | Tier C — Watch / trade | - |
| 贝美前列素/马来酸噻吗洛尔Bimatoprost/Timolol Maleate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-(4-Morpholinyl)-1,2,5-thiadiazol-3-ol→(+/-)-2-(Chloromethyl)oxirane→2-Methylpropan-2-amine→1-(tert-Butylamino)-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol→(S)-1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol→3,4-Dichloro-1,2,5-thiadiazole→Diethylene oximide→4-(4-chloro-1,2,5-thiadiazol-3-yl)morpholine→[(5S)-3-tert-Butyl-1,3-oxazolidin-5-yl]methanol
2-(Chloromethyl)oxirane→(R)-(-)-2-(Chloromethyl)oxirane→3-Chloropropane-1,2(S)-diol→4-(4-Morpholinyl)-1,2,5-thiadiazol-3-ol→(2R)-1-Chloro-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol→4-[4-[(2S)-Oxiran-2-ylmethoxy]-1,2,5-thiadiazol-3-yl]morpholine→Sodium 4-(morpholin-4-yl)-1,2,5-thiadiazol-3-olate→(2S)-3-[[4-(Morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propane-1,2-diol→2-Methylpropan-2-amine→(S)-1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
4-(4-Morpholinyl)-1,2,5-thiadiazol-3-ol→(+/-)-2-(Chloromethyl)oxirane→2-Methylpropan-2-amine→1-(tert-Butylamino)-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol→(S)-1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol→3,4-Dichloro-1,2,5-thiadiazole→Diethylene oximide→4-(4-chloro-1,2,5-thiadiazol-3-yl)morpholine→[(5S)-3-tert-Butyl-1,3-oxazolidin-5-yl]methanol
2-(Chloromethyl)oxirane→(R)-(-)-2-(Chloromethyl)oxirane→3-Chloropropane-1,2(S)-diol→4-(4-Morpholinyl)-1,2,5-thiadiazol-3-ol→(2R)-1-Chloro-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol→4-[4-[(2S)-Oxiran-2-ylmethoxy]-1,2,5-thiadiazol-3-yl]morpholine→Sodium 4-(morpholin-4-yl)-1,2,5-thiadiazol-3-olate→(2S)-3-[[4-(Morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propane-1,2-diol→2-Methylpropan-2-amine→(S)-1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.