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CAS 2747-08-2

2-bromo-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Codes:DONE-018

Application context (from source-drug indications)

阿尔茨海默病盐酸美金刚/盐酸多奈哌齐

Source drugs (routes using this intermediate)

DrugTierExpiry
盐酸美金刚/盐酸多奈哌齐Memantine Hydrochloride/Donepezil HydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

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盐酸美金刚/盐酸多奈哌齐优化路线steps: 3total yield: /
(chloromethyl)benzene→isonicotinaldehyde→5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one→2-bromo-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one→5,6-dimethoxy-3'-(pyridin-4-yl)spiro[indene-2,2'-oxiran]-1(3H)-one

Intermediates available on this site

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