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CAS 872-85-5
isonicotinaldehyde
Codes：DONE-009
Application context (from source-drug indications)
阿尔茨海默病盐酸美金刚/盐酸多奈哌齐
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 盐酸美金刚/盐酸多奈哌齐Memantine Hydrochloride/Donepezil Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(chloromethyl)benzene→isonicotinaldehyde→5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one→2-bromo-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one→5,6-dimethoxy-3'-(pyridin-4-yl)spiro[indene-2,2'-oxiran]-1(3H)-one
5,6-dimethoxy-2,3-dihydro-1H-inden-1-one→isonicotinaldehyde→(bromomethyl)benzene→1-benzyl-4-formylpyridin-1-ium bromide→(E)-1-benzyl-4-((5,6-dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)pyridin-1-ium bromide→(E)-2-((1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
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