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CAS 2778223-41-7
Methyl 4-cyano-1-methoxycyclohexane-1-carboxylate
Codes：(I)1024528-3-a,(I)1024528-3-b
Application context (from source-drug indications)
非小细胞肺癌普拉替尼甲状腺瘤普拉替尼甲状腺髓样癌普拉替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 普拉替尼Pralsetinib | Tier C — Watch / trade | 2031 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Methyl 4-cyano-1-methoxycyclohexane-1-carboxylate→Methyl 4-[imino(methoxy)methyl]-1-methoxycyclohexane-1-carboxylate hydrogen chloride→Methyl trans-4-carbamimidoyl-1-methoxycyclohexane-1-carboxylate→1-Methoxybutane-1,3-dione→Methyl 1-methoxy-4-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyclohexane-1-carboxylate→Methyl trans-4-[4-[(methanesulfonyl)oxy]-6-methylpyrimidin-2-yl]-1-methoxycyclohexane-1-carboxylate→3-Amino-5-methylpyrazole→Methyl (1s,4s)-1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxylate→(1s,4s)-1-Methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxylic acid→(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine→(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine hydrogen chloride
Methyl 4-cyano-1-methoxycyclohexane-1-carboxylate→(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine hydrogen chloride→1,4 Cyclohexanedione ethylene ketal→Methyl 8-methoxy-1,4-dioxaspiro[4.5]decane-8-carboxylate→Methyl 1-methoxy-4-oxocyclohexane-1-carboxylate→1,4-Dioxaspiro[4.5]decane-8-carbonitrile→4-Oxocyclohexane-1-carbonitrile
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