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CAS 4746-97-8
1,4 Cyclohexanedione ethylene ketal
Codes：(I)1024528-1-a,(I)1024528-1-d、(XI)1024528-3-b
Application context (from source-drug indications)
非小细胞肺癌普拉替尼甲状腺瘤普拉替尼甲状腺髓样癌普拉替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 普拉替尼Pralsetinib | Tier C — Watch / trade | 2031 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,4 Cyclohexanedione ethylene ketal→Methyl 8-methoxy-1,4-dioxaspiro[4.5]decane-8-carboxylate→Methyl 1-methoxy-4-oxocyclohexane-1-carboxylate→Methyl 4-hydroxy-1-methoxycyclohexane-1-carboxylate→Methyl 4-iodo-1-methoxycyclohexane-1-carboxylate→2-Chloro-4-methyl-6-(methylsulfanyl)pyrimidine→2,4-Dichloro-6-methylpyrimidine→Methyl 1-methoxy-4-[4-methyl-6-(methylsulfanyl)pyrimidin-2-yl]cyclohexane-1-carboxylate→Methyl 4-[4-(methanesulfonyl)-6-methylpyrimidin-2-yl]-1-methoxycyclohexane-1-carboxylate→Methyl 1-methoxy-4-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyclohexane-1-carboxylate→Methyl 4-(4-chloro-6-methylpyrimidin-2-yl)-1-methoxycyclohexane-1-carboxylate
1,4 Cyclohexanedione ethylene ketal→Methyl 1-methoxy-4-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyclohexane-1-carboxylate→1,4-Dioxaspiro[4.5]decane-8-carbonitrile→N-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboximidamide→1,4-Dioxaspiro[4.5]decane-8-carboximidamide→1-Ethoxybutane-1,3-dione→2-(1,4-Dioxaspiro[4.5]decan-8-yl)-6-methylpyrimidin-4-ol→4-(4-Hydroxy-6-methylpyrimidin-2-yl)cyclohexan-1-one
Methyl 4-cyano-1-methoxycyclohexane-1-carboxylate→(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine hydrogen chloride→1,4 Cyclohexanedione ethylene ketal→Methyl 8-methoxy-1,4-dioxaspiro[4.5]decane-8-carboxylate→Methyl 1-methoxy-4-oxocyclohexane-1-carboxylate→1,4-Dioxaspiro[4.5]decane-8-carbonitrile→4-Oxocyclohexane-1-carbonitrile
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