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CAS 296242-38-1
(2S,3S,5R)-2-hexyl-3-hydroxy-5-((triisopropylsilyl)oxy)hexadecanoic acid
Codes: ORLI-059
Application context (from source-drug indications)
ObesityOrlistatI型高脂蛋白血症OrlistatHypertriglyceridaemiaOrlistat女性不孕OrlistatDiabetesOrlistatObstructive sleep apnoea syndromeOrlistat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Orlistat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)oxetan-2-one→(S)-2-formamido-4-methylpentanoic acid→N-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-4-methylbenzenesulfonamide→octanoyl chloride→(1S,2R)-1-(4-methylphenylsulfonamido)-2,3-dihydro-1H-inden-2-yl octanoate→cinnamaldehyde→(S)-(1S,2R)-1-(4-methylphenylsulfonamido)-2,3-dihydro-1H-inden-2-yl 2-((S,E)-1-hydroxy-3-phenylallyl)octanoate→(S)-2-((S,E)-1-hydroxy-3-phenylallyl)octanoic acid→(2S,5S,6S)-2-(tert-butyl)-5-hexyl-6-((E)-styryl)-1,3-dioxan-4-one→(2S,4R,5S)-2-(tert-butyl)-5-hexyl-6-oxo-1,3-dioxane-4-carbaldehyde→1-nitrododecane→(2S,5S,6R)-2-(tert-butyl)-5-hexyl-6-((1S)-1-hydroxy-2-nitrotridecyl)-1,3-dioxan-4-one→(2S,5S,6S)-2-(tert-butyl)-5-hexyl-6-((Z)-2-nitrotridec-1-en-1-yl)-1,3-dioxan-4-one→(2S,5S,6S)-2-(tert-butyl)-5-hexyl-6-((E)-2-(hydroxyimino)tridecyl)-1,3-dioxan-4-one→(2S,5S,6S)-2-(tert-butyl)-5-hexyl-6-(2-oxotridecyl)-1,3-dioxan-4-one→(2S,3S)-2-hexyl-3-hydroxy-5-oxohexadecanoic acid→(2S,3S)-benzyl 2-hexyl-3-hydroxy-5-oxohexadecanoate→(2S,3S,5R)-benzyl 2-hexyl-3,5-dihydroxyhexadecanoate→(2S,3S,5R)-benzyl 2-hexyl-3-hydroxy-5-((triisopropylsilyl)oxy)hexadecanoate→(2S,3S,5R)-2-hexyl-3-hydroxy-5-((triisopropylsilyl)oxy)hexadecanoic acid→(3S,4S)-3-hexyl-4-((R)-2-((triisopropylsilyl)oxy)tridecyl)oxetan-2-one
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