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CAS 104872-06-2
(3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)oxetan-2-one
Codes: ORLI-020
Application context (from source-drug indications)
ObesityOrlistatI型高脂蛋白血症OrlistatHypertriglyceridaemiaOrlistat女性不孕OrlistatDiabetesOrlistatObstructive sleep apnoea syndromeOrlistat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Orlistat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-2-hydroxysuccinic acid→cyclohexanone→(S)-2-(3-oxo-1,4-dioxaspiro[4.5]decan-2-yl)acetic acid→(S)-3-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-1,4-dioxaspiro[4.5]decan-2-one→(S)-methyl 4-((tert-butyldiphenylsilyl)oxy)-2-hydroxybutanoate→ORLI-006→(S)-tert-butyl(2-(oxiran-2-yl)ethoxy)diphenylsilane→1-bromodecane→(R)-1-((tert-butyldiphenylsilyl)oxy)tetradecan-3-ol→benzyl 2,2,2-trichloroacetimidate→(R)-((3-(benzyloxy)tetradecyl)oxy)(tert-butyl)diphenylsilane→(R)-3-(benzyloxy)tetradecan-1-ol→(R)-3-(benzyloxy)tetradecanal→(E)-trimethyl(non-2-en-1-yl)silane→(7R,8S,10R)-10-(benzyloxy)-7-vinylhenicosan-8-ol→(((7R,8S,10R)-10-(benzyloxy)-7-vinylhenicosan-8-yl)oxy)(tert-butyl)dimethylsilane→(2S,3S,5R)-5-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)-2-hexylhexadecanoic acid→(2S,3S,5R)-5-(benzyloxy)-2-hexyl-3-hydroxyhexadecanoic acid→(3S,4S)-4-((R)-2-(benzyloxy)tridecyl)-3-hexyloxetan-2-one→(3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)oxetan-2-one→(S)-2-formamido-4-methylpentanoic acid
(3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)oxetan-2-one→(S)-2-formamido-4-methylpentanoic acid→N-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-4-methylbenzenesulfonamide→octanoyl chloride→(1S,2R)-1-(4-methylphenylsulfonamido)-2,3-dihydro-1H-inden-2-yl octanoate→cinnamaldehyde→(S)-(1S,2R)-1-(4-methylphenylsulfonamido)-2,3-dihydro-1H-inden-2-yl 2-((S,E)-1-hydroxy-3-phenylallyl)octanoate→(S)-2-((S,E)-1-hydroxy-3-phenylallyl)octanoic acid→(2S,5S,6S)-2-(tert-butyl)-5-hexyl-6-((E)-styryl)-1,3-dioxan-4-one→(2S,4R,5S)-2-(tert-butyl)-5-hexyl-6-oxo-1,3-dioxane-4-carbaldehyde→1-nitrododecane→(2S,5S,6R)-2-(tert-butyl)-5-hexyl-6-((1S)-1-hydroxy-2-nitrotridecyl)-1,3-dioxan-4-one→(2S,5S,6S)-2-(tert-butyl)-5-hexyl-6-((Z)-2-nitrotridec-1-en-1-yl)-1,3-dioxan-4-one→(2S,5S,6S)-2-(tert-butyl)-5-hexyl-6-((E)-2-(hydroxyimino)tridecyl)-1,3-dioxan-4-one→(2S,5S,6S)-2-(tert-butyl)-5-hexyl-6-(2-oxotridecyl)-1,3-dioxan-4-one→(2S,3S)-2-hexyl-3-hydroxy-5-oxohexadecanoic acid→(2S,3S)-benzyl 2-hexyl-3-hydroxy-5-oxohexadecanoate→(2S,3S,5R)-benzyl 2-hexyl-3,5-dihydroxyhexadecanoate→(2S,3S,5R)-benzyl 2-hexyl-3-hydroxy-5-((triisopropylsilyl)oxy)hexadecanoate→(2S,3S,5R)-2-hexyl-3-hydroxy-5-((triisopropylsilyl)oxy)hexadecanoic acid→(3S,4S)-3-hexyl-4-((R)-2-((triisopropylsilyl)oxy)tridecyl)oxetan-2-one
(3S,4S)-4-((R)-2-(benzyloxy)tridecyl)-3-hexyloxetan-2-one→(3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)oxetan-2-one→(S)-2-formamido-4-methylpentanoic acid→methyl 3-oxotetradecanoate→methyl (R)-3-hydroxytetradecanoate→2-bromooctanoyl bromide→(3R)-methyl 3-((2-bromooctanoyl)oxy)tetradecanoate→(R)-3-hexyl-4-hydroxy-6-undecyl-5,6-dihydro-2H-pyran-2-one→(3S,4S,6R)-3-hexyl-4-hydroxy-6-undecyltetrahydro-2H-pyran-2-one→(S)-1-phenylethanamine (2S,3S,5R)-5-(benzyloxy)-2-hexyl-3-hydroxyhexadecanoate
(3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)oxetan-2-one→(S)-2-formamido-4-methylpentanoic acid→1-iodohexane→dodecanal→ethynyltrimethylsilane→1-(trimethylsilyl)tetradec-1-yn-3-ol→tetradec-1-yn-3-ol→(S)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole→(R)-tetradec-1-yn-3-ol→(R)-1-methoxy-4-((tetradec-1-yn-3-yloxy)methyl)benzene→benzo[d][1,3,2]dioxaborole→(R)-3-((4-methoxybenzyl)oxy)tetradecanal→((1-(benzyloxy)vinyl)oxy)(tert-butyl)dimethylsilane→(3S,5R)-benzyl 3-hydroxy-5-((4-methoxybenzyl)oxy)hexadecanoate→(2S,3S,5R)-benzyl 2-hexyl-3-hydroxy-5-((4-methoxybenzyl)oxy)hexadecanoate→(2S,3S,5R)-2-hexyl-3-hydroxy-5-((4-methoxybenzyl)oxy)hexadecanoic acid→2-methyl-6-nitrobenzoic anhydride→(3S,4S)-3-hexyl-4-((R)-2-((4-methoxybenzyl)oxy)tridecyl)oxetan-2-one
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