CAS 296277-76-4

1-(2,4-dimethoxybenzyl)urea

Codes：SORF-012

Application context (from source-drug indications)

甲状腺瘤甲苯磺酸索拉非尼肝细胞癌甲苯磺酸索拉非尼肾细胞癌甲苯磺酸索拉非尼侵袭性纤维瘤病甲苯磺酸索拉非尼肝癌甲苯磺酸索拉非尼骨髓增生性疾病甲苯磺酸索拉非尼

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
甲苯磺酸索拉非尼Sorafenib Tosylate	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

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甲苯磺酸索拉非尼优化路线steps: 2total yield: /

4-bromo-1-chloro-2-(trifluoromethyl)benzene→1-(2,4-dimethoxybenzyl)urea→1-(4-chloro-3-(trifluoromethyl)phenyl)urea→4-(4-bromophenoxy)-N-methylpicolinamide

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