甲苯磺酸索拉非尼
Tier B — Position earlySorafenib Tosylate
Targets：VEGFR1、KIT、VEGFR3、PDGFR-β、C-Raf、VEGFR2、FLT3、RET、B-raf
Brand：多吉美、Nexavar
Indications (approved)：甲状腺瘤、肝细胞癌、肾细胞癌
Regional status
Synthetic routes & intermediates5 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| SORF-001 | 98-98-6 | picolinic acid |
| SORF-002 | 51727-15-2 | 4-chloropicolinoyl chloride hydrochloride |
| SORF-003 | 220000-87-3 | 4-chloropicolinoyl chloride |
| SORF-004 | 123-30-8Available | 4-aminophenol |
| SORF-005 | 284462-37-9 | 4-(4-aminophenoxy)-N-methylpicolinamide |
| SORF-006 | 327-78-6 | 1-chloro-4-isocyanato-2-(trifluoromethyl)benzene |
| SORF-007 | 320-51-4Available | 4-chloro-3-(trifluoromethyl)aniline |
| Code | CAS No. | Intermediate |
|---|---|---|
| SORF-003 | 220000-87-3 | 4-chloropicolinoyl chloride |
| SORF-004 | 123-30-8Available | 4-aminophenol |
| SORF-007 | 320-51-4Available | 4-chloro-3-(trifluoromethyl)aniline |
| SORF-008 | 1566-41-2 | 1-(4-hydroxyphenyl)urea |
| SORF-009 | 1129683-83-5 | 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-hydroxyphenyl)urea |
| Code | CAS No. | Intermediate |
|---|---|---|
| SORF-001 | 98-98-6 | picolinic acid |
| SORF-003 | 220000-87-3 | 4-chloropicolinoyl chloride |
| SORF-004 | 123-30-8Available | 4-aminophenol |
| SORF-005 | 284462-37-9 | 4-(4-aminophenoxy)-N-methylpicolinamide |
| SORF-010 | 871555-75-8 | phenyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate |
| Code | CAS No. | Intermediate |
|---|---|---|
| SORF-011 | 445-01-2 | 4-bromo-1-chloro-2-(trifluoromethyl)benzene |
| SORF-012 | 296277-76-4 | 1-(2,4-dimethoxybenzyl)urea |
| SORF-013 | 343247-69-8 | 1-(4-chloro-3-(trifluoromethyl)phenyl)urea |
| SORF-014 | 1154243-75-0 | 4-(4-bromophenoxy)-N-methylpicolinamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| SORF-005 | 284462-37-9 | 4-(4-aminophenoxy)-N-methylpicolinamide |
| SORF-007 | 320-51-4Available | 4-chloro-3-(trifluoromethyl)aniline |
Frequently asked questions
What are the approved indications of Sorafenib Tosylate?
Approved indications include: 甲状腺瘤, 肝细胞癌, 肾细胞癌.
When does the Sorafenib Tosylate patent expire?
No public expiry year is available for Sorafenib Tosylate yet; this page updates once verified.
How many synthesis routes are recorded for Sorafenib Tosylate?
5 synthesis routes are recorded; the shortest is 1 steps with 2.21 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Sorafenib Tosylate intermediates?
2 intermediate CAS of Sorafenib Tosylate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Sorafenib Tosylate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24