CAS 2974-94-9

1-Iodo-4-phenoxybenzene

Codes：(IIa)461018-14-a

Application context (from source-drug indications)

华氏巨球蛋白血症伊布替尼慢性淋巴细胞白血病伊布替尼套细胞淋巴瘤伊布替尼移植物抗宿主病伊布替尼

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
伊布替尼Ibrutinib	Tier A — Act now	2027

Position in synthesis routes (up/downstream chain)

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伊布替尼优化路线steps: 2total yield: /

1H-Pyrazolo[3,4-d]pyrimidin-4-amine→3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→1-Iodo-4-phenoxybenzene→(4-Phenoxyphenyl)boranediol→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→1-[(3S)-3-Hydroxypiperidin-1-yl]prop-2-en-1-one→(3S)-Piperidin-3-ol--hydrogen chloride (1→2-Propenoic acid

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