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伊布替尼
Tier A — Act nowIbrutinib · all drugs expiring in 2027 →
Pharmacyclics Llc
Originator
2013
First approval
2027
Expiry (public)
$9.78B ▲
Peak sales
化学药
Type
Targets：BTK
Brand：Imbruvica、亿珂
Indications (approved)：华氏巨球蛋白血症、慢性淋巴细胞白血病、套细胞淋巴瘤、移植物抗宿主病
Regional status
US
批准上市
2013-11-13
EU
批准上市
2014-10-21
China
批准上市
2017-08-24
Japan
批准上市
2016-03-28
Synthetic routes & intermediates33 routes
Originator routes × 1Optimised (non-patent) × 32Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 8 · Total yield 22 mg
| Code | CAS No. | Intermediate |
|---|---|---|
| IBRT-001 | 2215-77-2Available | 4-phenoxybenzoic acid |
| IBRT-002 | 330792-68-2 | 2-(hydroxy(4-phenoxyphenyl)methylene)malononitrile |
| IBRT-003 | 330792-69-3 | 2-(methoxy(4-phenoxyphenyl)methylene)malononitrile |
| IBRT-004 | 330792-70-6Available | 5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile |
| IBRT-005 | 330786-24-8Available | 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| IBRT-006 | 143900-44-1Available | (S)-tert-butyl 3-hydroxypiperidine-1-carboxylate |
| IBRT-007 | 1022150-11-3 | (R)-tert-butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate |
| IBRT-008 | 814-68-6Available | acryloyl chloride |
| IBRT-009 | 2380-63-4 | 1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| IBRT-010 | 151266-23-8Available | 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| IBRT-011 | 51067-38-0 | tert-butyl 4-(((6-amino-5-chloropyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate |
OptimisedRoute 2Steps 3 · Total yield 3.2 g
| Code | CAS No. | Intermediate |
|---|---|---|
| IBRT-003 | 330792-69-3 | 2-(methoxy(4-phenoxyphenyl)methylene)malononitrile |
| IBRT-012 | 1623-95-6 | 4-phenoxybenzoyl chloride |
| IBRT-013 | 1574506-73-2 | (R)-1-(3-hydrazinylpiperidin-1-yl)prop-2-en-1-one |
| IBRT-014 | 1574506-72-1 | (R)-1-(1-acryloylpiperidin-3-yl)-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile |
OptimisedRoute 3Steps 4 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-2-a | 83255-86-1 | 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (II)461018-2-a | 51067-38-0 | (4-Phenoxyphenyl)boranediol |
| (III)461018-2-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (IV)461018-2-a | - | N-Boc-3(S)-Hydroxypiperidine |
| (IX)461018-2-a | 814-68-6Available | 2-Propenoyl chloride |
| (V)461018-2-a | 1022150-11-3 | (3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester |
| (VI)461018-2-a | 354-32-5 | Perfluoroacetyl chloride |
| (VII)461018-2-a | 1441076-08-9 | tert-Butyl (3R)-3-[3-(4-phenoxyphenyl)-4-[(trifluoroacetyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate |
| (VIII)461018-2-a | 1441076-09-0 | 2,2,2-Trifluoro-N-[3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]acetamide |
| (X)461018-2-a | 1441076-10-3 | N-[1-[(3R)-1-Acryloylpiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-2,2,2-trifluoroacetamide |
OptimisedRoute 4Steps 4 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-3-a | 1623-95-6 | 4-Phenoxybenzoyl chloride |
| (II)461018-3-a | 109-77-3 | 1,1-Dicyanomethane |
| (III)461018-3-a | 330792-68-2 | (4-Phenoxybenzoyl)malononitrile |
| (IV)461018-3-a | 330792-69-3 | 1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene |
| (V)461018-3-a | 1574506-73-2 | 1-[(3R)-3-Hydrazinopiperidin-1-yl]prop-2-en-1-one |
| (VI)461018-3-a | 1574506-72-1 | 1-[(3R)-1-Acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile |
| (VII)461018-3-a | 4637-24-5Available | (Dimethylamino)formaldehyde dimethyl acetal |
OptimisedRoute 5Steps 5 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-4-a | 2215-77-2Available | 4-(Phenyloxy)benzoic acid |
| (II)461018-4-a | 541-41-3 | Carbonochloridic acid ethyl ester |
| (III)461018-4-a | 1652601-99-4 | Ethyl 4-phenoxybenzoyl carbonate |
| (IV)461018-4-a | 109-77-3 | 1,1-Dicyanomethane |
| (IX)461018-4-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (V)461018-4-a | 330792-68-2 | (4-Phenoxybenzoyl)malononitrile |
| (VI)461018-4-a | 1824684-85-6 | [Chloro(4-phenoxyphenyl)methylene]malononitrile |
| (VII)461018-4-a | 330792-70-6Available | 3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole |
| (VIII)461018-4-a | 3473-63-0 | Formamidine acetate |
| (Xa)461018-4-a | 637338-78-4 | 3-Chloro-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (Xb)461018-4-a | 83255-86-1 | 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (Xc)461018-4-a | 151266-23-8Available | 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (Xd)461018-4-a | 2395781-95-8 | 4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-ylmethanesulfonate |
OptimisedRoute 6Steps 5 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-5-a | 21461-84-7 | (2S)-5-oxooxolane-2-carboxylic acid |
| (II)461018-5-a | 1798323-71-3 | (2S)-5-(Benzylamino)-2-hydroxy-5-oxopentanoic acid |
| (IIIa)461018-5-a | 1798323-73-5 | (3S)-1-Benzyl-2,6-dioxopiperidin-3-yl acetate |
| (IIIb)461018-5-a | 1798323-79-1 | (3S)-1-Benzyl-2,6-dioxopiperidin-3-yl chloroacetate |
| (IIIc)461018-5-a | 1798323-81-5 | (3S)-1-Benzyl-2,6-dioxopiperidin-3-yl trifluoroacetate |
| (IV)461018-5-a | 91599-79-0 | (3S)-1-Benzylpiperidin-3-ol |
| (V)461018-5-a | 1798323-76-8 | (3S)-Piperidin-3-ol acetate |
| (VI)461018-5-a | 143900-44-1Available | (3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine |
OptimisedRoute 7Steps 4 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-6-a | 143900-44-1Available | (3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine |
| (IIa)461018-6-a | 191092-08-7 | (S)-1-tert-Butoxycarbonyl-3-(p-toluenesulfonyloxymethyl)piperidine |
| (IIb)461018-6-a | 2315115-22-9 | tert-Butyl (3S)-3-[[tert-butyl(dimethyl)silyl]oxy]piperidine-1-carboxylate |
| (IIIa)461018-6-a | 1816998-80-7 | (3S)-Piperidin-3-yl 4-methylbenzenesulfonate |
| (IIIb)461018-6-a | 1374144-82-7 | (3S)-3-[[tert-Butyl(dimethyl)silyl]oxy]piperidine |
| (IV)461018-6-a | 814-68-6Available | 2-Propenoyl chloride |
| (V)461018-6-a | 79-10-7 | 2-Propenoic acid |
| (VIa)461018-6-a | 1816998-81-8 | (3S)-1-Acryloylpiperidin-3-yl 4-methylbenzenesulfonate |
| (VIb)461018-6-a | 1816998-83-0 | 1-[(3S)-3-[[tert-Butyl(dimethyl)silyl]oxy]piperidin-1-yl]prop-2-en-1-one |
| (VII)461018-6-a | 1816998-82-9 | (3S)-1-Acryloylpiperidin-3-yl 4-nitrobenzenesulfonate |
| (VIII)461018-6-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
OptimisedRoute 8Steps 4 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (Ia)461018-7-a | 101-55-3 | 1-Bromo-4-phenoxybenzene |
| (Ib)461018-7-a | - | 1,1'-Oxydibenzene |
| (II)461018-7-a | 5305-40-8 | 4,6-Dichloropyrimidine-5-carbaldehyde |
| (III)461018-7-a | 1850315-20-6 | (4,6-Dichloropyrimidin-5-yl)(4-phenoxyphenyl)methanol |
| (IV)461018-7-a | 1807637-54-2 | (4,6-Dichloropyrimidin-5-yl)(4-phenoxyphenyl)methanone |
| (V)461018-7-a | 1850315-21-7 | 4-Chloro-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine |
| (VI)461018-7-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
OptimisedRoute 9Steps 6 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-8-a | 16617-46-2 | 3-Amino-1H-pyrazole-4-carbonitrile |
| (II)461018-8-a,(II)461018-8-b | 75-12-7 | Amide c1 |
| (III)461018-8-a | 2380-63-4 | 1H-Pyrazolo[3,4-d]pyrimidin-4-amine |
| (IVa)461018-8-a | 151266-23-8Available | 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (IVb)461018-8-a | 83255-86-1 | 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (IX)461018-8-a | 814-68-6Available | 2-Propenoyl chloride |
| (V)461018-8-a | 143900-44-1Available | (3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine |
| (VI)461018-8-a | 940890-90-4 | (S)-1-(tert-Butoxycarbonyl)piperidin-3-yl methanesulfonate |
| (VIIa)461018-8-a | 1276110-38-3 | tert-Butyl (3R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate |
| (VIIb)461018-8-a,(VIIb)461018-8-b | 1419223-01-0 | tert-Butyl (3R)-3-(4-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate |
| (VIIIa)461018-8-a | 1928705-12-7 | 3-Iodo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrogen chloride |
| (VIIIb)461018-8-a | 1928705-14-9 | 3-Bromo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VIIIc)461018-8-a | 1989746-21-5 | 3-Iodo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine--hydrogen chloride (1 |
| (VIIId)461018-8-a | 1638522-98-1 | 3-Iodo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (X)461018-8-a | 79-10-7 | 2-Propenoic acid |
| (XIa)461018-8-a | 1873339-79-7 | 1-[(3R)-3-(4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]prop-2-en-1-one |
| (XIb)461018-8-a | 1928705-13-8 | 1-[(3R)-3-(4-Amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]prop-2-en-1-one |
| (XII)461018-8-a | 51067-38-0 | (4-Phenoxyphenyl)boranediol |
| (XIIIa)461018-8-a | 625-36-5Available | (Chloromethyl)acetyl chloride |
| (XIIIb)461018-8-a | 7623-16-7 | 3-Bromopropanoyl bromide |
| (XIVa)461018-8-a | 1985609-75-3 | 1-[(3R)-3-(4-Amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]-3-chloropropan-1-one |
| (XIVb)461018-8-a | 1985609-76-4 | 1-[(3R)-3-(4-Amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]-3-bromopropan-1-one |
OptimisedRoute 10Steps 6 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-9-a | 42839-04-3 | Pyrimidine-4-carbonitrile |
| (II)461018-9-a | 939986-65-9 | 6-Chloropyrimidine-4-carbonitrile |
| (III)461018-9-a | 870-46-2 | (tert-Butoxycarbonyl)hydrazine |
| (IV)461018-9-a | 2408965-53-5 | 6-Hydrazinylpyrimidine-4-carbonitrile hydrogen chloride |
| (IXa)461018-9-a | 625-36-5Available | (Chloromethyl)acetyl chloride |
| (IXb)461018-9-a | 15486-96-1 | 3-Bromopropanoyl chloride |
| (IXc)461018-9-a | 7623-16-7 | 3-Bromopropanoyl bromide |
| (V)461018-9-a | 67-36-7 | 4-Phenoxybenzaldehyde |
| (VI)461018-9-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VII)461018-9-a | 1354010-30-2 | N-Boc-3(S)-chloropiperidine |
| (VIII)461018-9-a | 1022150-12-4Available | (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (Xa)461018-9-a | 1288338-96-4 | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-chloropropan-1-one |
| (Xb)461018-9-a | 1899029-09-4 | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-bromopropan-1-one |
OptimisedRoute 11Steps 4 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-10-a | 1193-24-4 | 4,6-Dihydroxypyrimidine |
| (II)461018-10-a | 5305-40-8 | 4,6-Dichloropyrimidine-5-carbaldehyde |
| (III)461018-10-a | 101-55-3 | 1-Bromo-4-phenoxybenzene |
| (IV)461018-10-a | 1850315-20-6 | (4,6-Dichloropyrimidin-5-yl)(4-phenoxyphenyl)methanol |
| (IX)461018-10-a | 1022150-11-3 | (3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester |
| (V)461018-10-a | 1807637-54-2 | (4,6-Dichloropyrimidin-5-yl)(4-phenoxyphenyl)methanone |
| (VI)461018-10-a | 1807637-55-3 | (4-Amino-6-chloropyrimidin-5-yl)(4-phenoxyphenyl)methanone |
| (VII)461018-10-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VIII)461018-10-a | 1354010-30-2 | N-Boc-3(S)-chloropiperidine |
| (Xa)461018-10-a | 1022150-12-4Available | (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (Xb)461018-10-a | 1553977-42-6 | 3-(4-Phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrogen chloride |
| (XI)461018-10-a | 814-68-6Available | 2-Propenoyl chloride |
| (XII)461018-10-a | 625-36-5Available | (Chloromethyl)acetyl chloride |
OptimisedRoute 12Steps 5 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-11-a | 2380-63-4 | 1H-Pyrazolo[3,4-d]pyrimidin-4-amine |
| (II)461018-11-a | 83255-86-1 | 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (IIIa)461018-11-a | 143900-44-1Available | (3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine |
| (IIIb)461018-11-a | 940890-90-4 | (S)-1-(tert-Butoxycarbonyl)piperidin-3-yl methanesulfonate |
| (IVa)461018-11-a | 1419223-01-0 | tert-Butyl (3R)-3-(4-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate |
| (IVb)461018-11-a | 1276110-38-3 | tert-Butyl (3R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate |
| (V)461018-11-a | 151266-23-8Available | 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VIa)461018-11-a | 1985609-74-2 | 3-Bromo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrogen chloride (1/2) |
| (VIb)461018-11-a | 1989746-21-5 | 3-Iodo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine--hydrogen chloride (1/2) |
| (VIc)(IX)461018-11-a | 1553977-42-6 | 3-(4-Phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrogen chloride |
| (VII)461018-11-a | 51067-38-0 | (4-Phenoxyphenyl)boranediol |
| (VIII)461018-11-a | 1022150-12-4Available | (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (X)461018-11-a | 814-68-6Available | 2-Propenoyl chloride |
OptimisedRoute 13Steps 3 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-12-a | 143900-44-1Available | (3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine |
| (II)461018-12-a | 191092-08-7 | (S)-1-tert-Butoxycarbonyl-3-(p-toluenesulfonyloxymethyl)piperidine |
| (IIIa)461018-12-a | 83255-86-1 | 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (IIIb)461018-12-a | 151266-23-8Available | 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (IVa)461018-12-a | 1419223-01-0 | tert-Butyl (3R)-3-(4-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate |
| (IVb)461018-12-a | 1276110-38-3 | tert-Butyl (3R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate |
| (Va)461018-12-a | 1928705-14-9 | 3-Bromo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (Vb)461018-12-a | 1638522-98-1 | 3-Iodo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VI)461018-12-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VII)461018-12-a | 1022150-11-3 | (3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester |
| (VIII)461018-12-a | 1022150-12-4Available | (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
OptimisedRoute 14Steps 2 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-13-a | 1022150-12-4Available | (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (IIa)461018-13-a | 7623-09-8 | 1,2 Dichloro-1-propanone |
| (IIb)461018-13-a | 563-76-8 | 2-Bromopropanoyl bromide |
| (IIIa)461018-13-a | 1906970-58-8 | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2-chloropropan-1-one |
| (IIIb)461018-13-a | 1906970-57-7 | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2-bromopropan-1-one |
OptimisedRoute 15Steps 2 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (Ia)461018-14-a | 2380-63-4 | 1H-Pyrazolo[3,4-d]pyrimidin-4-amine |
| (Ib)461018-14-a | 83255-86-1 | 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (IIa)461018-14-a | 2974-94-9 | 1-Iodo-4-phenoxybenzene |
| (IIb)461018-14-a | 51067-38-0 | (4-Phenoxyphenyl)boranediol |
| (III)461018-14-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (IV)461018-14-a | 1642601-01-1 | 1-[(3S)-3-Hydroxypiperidin-1-yl]prop-2-en-1-one |
| (V)461018-14-a | 475058-41-4 | (3S)-Piperidin-3-ol--hydrogen chloride (1 |
| (VI)461018-14-a | 79-10-7 | 2-Propenoic acid |
OptimisedRoute 16Steps 4 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-15-a | 87600-98-4 | 4,6-Dichloropyrimidine-5-carboxylic acid |
| (II)461018-15-a | 87600-97-3 | 4,6-Dichloropyrimidine-5-carbonyl chloride |
| (III)461018-15-a | - | 1,1'-Oxydibenzene |
| (IV)461018-15-a | 1807637-54-2 | (4,6-Dichloropyrimidin-5-yl)(4-phenoxyphenyl)methanone |
| (V)461018-15-a | 1807637-55-3 | (4-Amino-6-chloropyrimidin-5-yl)(4-phenoxyphenyl)methanone |
| (VIa)461018-15-a | 302-01-2 | Diamine |
| (VIb)461018-15-a | 30929-57-8 | Cyclohexylhydrazine hydrogen chloride |
| (VIIa)461018-15-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VIIb)461018-15-a | 1914997-73-1 | 1-Cyclohexyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
OptimisedRoute 17Steps 4 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-17-a | 475058-41-4 | (3S)-Piperidin-3-ol--hydrogen chloride (1 |
| (II)461018-17-a | 1126736-20-6 | 2,2,2-Trifluoro-1-[(3S)-3-hydroxypiperidin-1-yl]ethan-1-one |
| (III)461018-17-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (IV)461018-17-a | 1906970-30-6 | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2,2,2-trifluoroethan-1-one |
| (V)461018-17-a | 2095781-68-1 | 2,2,2-Trifluoro-1-[(3R)-3-[3-(4-phenoxyphenyl)-4-[(triphenyl-lambda5-phosphanylidene)amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethan-1-one |
| (VI)461018-17-a | 1022150-12-4Available | (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VII)461018-17-a | 814-68-6Available | 2-Propenoyl chloride |
OptimisedRoute 18Steps 2 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (Ia)461018-18-a | 2088495-73-0 | Benzyl (3R)-3-(4-[[(benzyloxy)carbonyl]amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate |
| (Ib)461018-18-a | 2088495-74-1 | tert-Butyl (3R)-3-[4-[(tert-butoxycarbonyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate |
| (II)461018-18-a | 101-55-3 | 1-Bromo-4-phenoxybenzene |
| (IIIa)461018-18-a | 2088495-71-8 | Benzyl (3R)-3-[4-[[(benzyloxy)carbonyl]amino]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate |
| (IIIb)461018-18-a | 2088495-72-9 | tert-Butyl (3R)-3-[4-[(tert-butoxycarbonyl)amino]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate |
| (IV)461018-18-a | 1022150-12-4Available | (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
OptimisedRoute 19Steps 1 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-19-a | 1846596-88-0 | tert-Butyl (3R)-3-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate |
| (II)461018-19-a | 101-55-3 | 1-Bromo-4-phenoxybenzene |
| (III)461018-19-a | 1022150-11-3 | (3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester |
OptimisedRoute 20Steps 6 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-20-a | 143900-44-1Available | (3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine |
| (II)461018-20-a | 475058-41-4 | (3S)-Piperidin-3-ol--hydrogen chloride (1 |
| (III)461018-20-a | 91599-79-0 | (3S)-1-Benzylpiperidin-3-ol |
| (IV)461018-20-a | 2121460-13-5 | (3S)-1-Benzylpiperidin-3-yl methanesulfonate |
| (IX)461018-20-a | 79-10-7 | 2-Propenoic acid |
| (V)461018-20-a | 2760218-96-8 | (3S)-Piperidin-3-yl methanesulfonate |
| (VI)461018-20-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VII)461018-20-a | 2012523-61-2 | 1-[(3R)-1-Benzylpiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VIII)461018-20-a | 1022150-12-4Available | (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (X)461018-20-a | 814-68-6Available | 2-Propenoyl chloride |
| (XI)461018-20-a | 1642601-01-1 | 1-[(3S)-3-Hydroxypiperidin-1-yl]prop-2-en-1-one |
| (XII)461018-20-a | 1820971-88-7 | (3S)-1-(Prop-2-enoyl)piperidin-3-yl methanesulfonate |
OptimisedRoute 21Steps 4 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-21-a | 143900-44-1Available | (3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine |
| (II)461018-21-a | - | (3S)-1-(3,3-Dimethylbutanoyl)piperidin-3-yl 4-methylbenzene-1-sulfonate |
| (III)461018-21-a | 1816998-80-7 | (3S)-Piperidin-3-yl 4-methylbenzenesulfonate |
| (IV)461018-21-a | 814-68-6Available | 2-Propenoyl chloride |
| (IX)461018-21-a | 51067-38-0 | (4-Phenoxyphenyl)boranediol |
| (V)461018-21-a | 1816998-81-8 | (3S)-1-Acryloylpiperidin-3-yl 4-methylbenzenesulfonate |
| (VI)461018-21-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VII)461018-21-a | 2380-63-4 | 1H-Pyrazolo[3,4-d]pyrimidin-4-amine |
| (VIII)461018-21-a | 151266-23-8Available | 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
OptimisedRoute 22Steps 4 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-22-a | 67-36-7 | 4-Phenoxybenzaldehyde |
| (II)461018-22-a | 109-77-3 | 1,1-Dicyanomethane |
| (III)461018-22-a | 64781-22-2 | [(4-Phenoxyphenyl)methylidene]propanedinitrile |
| (IV)461018-22-a | 10217-52-4,7803-57-8 | Hydrazine hydrate |
| (IX)461018-22-a | 1576-35-8 | 4-Methylbenzenesulfonhydrazide |
| (V)461018-22-a | 2097595-50-9 | 5-Amino-3-(4-phenoxyphenyl)-2,3-dihydro-1H-pyrazole-4-carbonitrile |
| (VI)461018-22-a | 2097595-51-0 | 3-(4-Phenoxyphenyl)-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VII)461018-22-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VIII)461018-22-a | 330792-70-6Available | 3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole |
| (X)461018-22-a | - | 4-Methyl-N'-[(4-phenoxyphenyl)methyl]benzene-1-sulfonohydrazide |
| (XI)461018-22-a | 75-12-7 | Amide c1 |
OptimisedRoute 23Steps 1 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-23-a | 79-10-7 | 2-Propenoic acid |
| (II)461018-23-a | 1022150-12-4Available | (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
OptimisedRoute 24Steps 1 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-24-a | 85275-45-2 | 1-Boc-3-hydroxypiperidine |
| (II)461018-24-a | 2222128-84-7 | N-Boc-3(S)-Piperidinyl butyrate |
OptimisedRoute 25Steps 6 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-25-a | 188111-79-7 | (3R)-3-Amino-1-piperidinecarboxylic acid 1,1-dimethylethyl ester |
| (II)461018-25-a,(II)461018-25-b | 2138465-88-8 | tert-Butyl (3R)-3-[(tert-butoxycarbonyl)(nitroso)amino]piperidine-1-carboxylate |
| (III)461018-25-a | 2138465-89-9 | tert-Butyl (3R)-3-[1-(tert-butoxycarbonyl)hydrazinyl]piperidine-1-carboxylate |
| (IV)461018-25-a | 1914997-74-2 | (3R)-3-Hydrazinylpiperidine |
| (IX)461018-25-a | 75-12-7 | Amide c1 |
| (V)461018-25-a | 330792-69-3 | 1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene |
| (VI)461018-25-a | 1623-95-6 | 4-Phenoxybenzoyl chloride |
| (VII)461018-25-a | 109-77-3 | 1,1-Dicyanomethane |
| (VIII)461018-25-a | 2138465-90-2 | 5-Amino-3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazole-4-carbonitrile |
| (X)461018-25-a | 1628179-43-0 | (3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbaldehyde |
| (XI)461018-25-a | 814-68-6Available | 2-Propenoyl chloride |
| (XII)461018-25-b | 54012-73-6Available | 3-Aminopiperidine |
| (XIII)461018-25-b | 2161366-04-5 | 5-Oxo-D-proline (3R)-piperidin-3-amine |
| (XIV)461018-25-b | 1263078-12-1 | tert-Butyl (3R)-3-[(tert-butoxycarbonyl)amino]piperidine-1-carboxylate |
OptimisedRoute 26Steps 4 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-26-a | 110-86-1 | Azabenzene |
| (II)461018-26-a | 636-73-7Available | 3-Pyridylsulfonic acid |
| (III)461018-26-a | 109-00-2 | 3-Hydroxypyridine |
| (IV)461018-26-a | 6859-99-0 | 3-Hydroxypiperidine |
| (IX)461018-26-a | 167112-94-9 | (2S,3S)-4-[(4-Chlorophenyl)amino]-2,3-dihydroxy-4-oxobutanoic acid (3S)-piperidin-3-ol |
| (V)461018-26-a | 14813-01-5 | 1-(Phenylmethyl)-3-piperidinol |
| (VI)461018-26-a | 46834-56-4 | (2S,3S)-4-((4-Chlorophenyl)amino)-2,3-dihydroxy-4-oxobutanoic acid |
| (VII)461018-26-a | 147-71-7Available | (2S,3S)-(-)-Tartaric acid |
| (VIII)461018-26-a | 106-47-8 | 1-Amino-4-chlorobenzene |
| (X)461018-26-a | 143900-44-1Available | (3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine |
OptimisedRoute 27Steps 6 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-27-a | 109-77-3 | 1,1-Dicyanomethane |
| (II)461018-27-a | 122-51-0Available | (Diethoxymethoxy)ethane |
| (III)461018-27-a | 123-06-8 | (Ethoxymethylene)malononitrile |
| (IV)461018-27-a | 2161366-06-7 | N-Boc-3(R)-hydrazinylpiperidine |
| (IX)461018-27-a | 51067-38-0 | (4-Phenoxyphenyl)boranediol |
| (V)461018-27-a | 2685868-56-6 | tert-Butyl (3R)-3-(5-amino-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate |
| (VI)461018-27-a | 75-12-7 | Amide c1 |
| (VII)461018-27-a | 1846596-88-0 | tert-Butyl (3R)-3-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate |
| (VIII)461018-27-a | 1419223-01-0 | tert-Butyl (3R)-3-(4-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate |
| (X)461018-27-a | 1022150-12-4Available | (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (XI)461018-27-a | 40736-25-2 | 1-(1H-Imidazol-1-yl)prop-2-en-1-one |
| (XII)461018-27-a | 2183504-50-7 | 5-Chloro-1-[(prop-2-enoyl)oxy]-1H-benzotriazole |
OptimisedRoute 28Steps 7 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-28-a | 1276110-38-3 | tert-Butyl (3R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate |
| (II)461018-28-a | 146631-00-7 | 1-Benzyloxy-4-boronic acid |
| (III)461018-28-a | 2096372-44-8 | tert-Butyl (3R)-3-[4-amino-3-[4-(benzyloxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate |
| (IV)461018-28-a | 2396827-24-8 | tert-Butyl (3R)-3-[3-[4-(benzyloxy)phenyl]-4-[bis(tert-butoxycarbonyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate |
| (IX)461018-28-a | 1044519-48-3 | ([13C]-1,2,3,4,5,6)Phenylboronic acid |
| (V)461018-28-a | 2396827-25-9 | tert-Butyl (3R)-3-[4-[bis(tert-butoxycarbonyl)amino]-3-(4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate |
| (VI)461018-28-a | 2719735-93-8 | tert-Butyl (3R)-3-[4-[bis(tert-butoxycarbonyl)amino]-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate |
| (VII)461018-28-a | 71597-85-8 | (4-Hydroxyphenyl)boronic acid |
| (VIII)461018-28-a | 112630-77-0 | 1-Bromo(13C6)benzene |
| (X)461018-28-a | - | tert-Butyl (3R)-3-(4-[bis(tert-butoxycarbonyl)amino]-3-[4-[([13C]-1,2,3,4,5,6)phenyloxy]phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate |
| (XI)461018-28-a | - | 3-[4-[([13C]-1,2,3,4,5,6)Phenyloxy]phenyl]-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (XII)461018-28-a | 814-68-6Available | 2-Propenoyl chloride |
| (XIII)461018-28-a | 2719735-92-7 | 1-[(3R)-3-(4-Amino-3-[4-[([13C]-1,2,3,4,5,6)phenyloxy]phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]prop-2-en-1-one |
OptimisedRoute 29Steps 2 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-29-a | 330792-70-6Available | 3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole |
| (II)461018-29-a | 1642601-01-1 | 1-[(3S)-3-Hydroxypiperidin-1-yl]prop-2-en-1-one |
| (III)461018-29-a | 1574506-72-1 | 1-[(3R)-1-Acryloylpiperidin-3-yl]-5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile |
| (IV)461018-29-a | 75-12-7 | Amide c1 |
OptimisedRoute 30Steps 5 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-31-a | 17180-93-7 | 4-Chloropyrimidine |
| (II)461018-31-a | 2759281-34-8 | tert-Butyl (3R)-3-[2-(tert-butoxycarbonyl)hydrazinyl]piperidine-1-carboxylate |
| (III)461018-31-a | 2759281-35-9 | tert-Butyl (3R)-3-[2-(tert-butoxycarbonyl)-1-(pyrimidin-4-yl)hydrazinyl]piperidine-1-carboxylate |
| (IV)461018-31-a | 2759281-36-0 | 4-Bromo-6-[1-[(3R)-piperidin-3-yl]hydrazinyl]pyrimidine |
| (V)461018-31-a | 67-36-7 | 4-Phenoxybenzaldehyde |
| (VI)461018-31-a | 2759281-37-1 | 4-Bromo-3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidine |
| (VII)461018-31-a | 1022150-12-4Available | (R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VIII)461018-31-a | 814-68-6Available | 2-Propenoyl chloride |
OptimisedRoute 31Steps 5 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-32-a | 143900-44-1Available | (3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine |
| (II)461018-32-a | 191092-08-7 | (S)-1-tert-Butoxycarbonyl-3-(p-toluenesulfonyloxymethyl)piperidine |
| (III)461018-32-a | 1816998-80-7 | (3S)-Piperidin-3-yl 4-methylbenzenesulfonate |
| (IV)461018-32-a | 625-36-5Available | (Chloromethyl)acetyl chloride |
| (V)461018-32-a | - | (3S)-1-(3-Chloropropanoyl)piperidin-3-yl 4-methylbenzene-1-sulfonate |
| (VI)461018-32-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (VII)461018-32-a | 1288338-96-4 | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-chloropropan-1-one |
OptimisedRoute 32Steps 2 · Total yield /
OptimisedRoute 33Steps 5 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)461018-34-a | 330786-24-8Available | 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| (II)461018-34-a | - | Di-tert-butyl [3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-2-imidodicarbonate |
| (III)461018-34-a | 91599-79-0 | (3S)-1-Benzylpiperidin-3-ol |
| (IV)461018-34-a | - | Di-tert-butyl [1-[(3R)-1-benzylpiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-2-imidodicarbonate |
| (IX)461018-34-a | 13618-91-2 | 4,5,6,7-Tetrahydro-1H-indole |
| (V)461018-34-a | - | Di-tert-butyl [3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-2-imidodicarbonate |
| (VI)461018-34-a | 814-68-6Available | 2-Propenoyl chloride |
| (VII)461018-34-a | - | Di-tert-butyl [3-(4-phenoxyphenyl)-1-[(3R)-1-(prop-2-enoyl)piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-2-imidodicarbonate |
| (VIII)461018-34-a | 16466-61-8 | Di-tert-butyl hydrazine-1,2-dicarboxylate |
| (X)461018-34-a | - | N'-(4,5,6,7-Tetrahydro-1H-indole-1-carbonyl)-4,5,6,7-tetrahydro-1H-indole-1-carbohydrazide |
Frequently asked questions
What are the approved indications of Ibrutinib?
Approved indications include: 华氏巨球蛋白血症, 慢性淋巴细胞白血病, 套细胞淋巴瘤, 移植物抗宿主病.
When does the Ibrutinib patent expire?
Based on public sources, the Ibrutinib patent expires in 2027.
How many synthesis routes are recorded for Ibrutinib?
33 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Ibrutinib intermediates?
15 intermediate CAS of Ibrutinib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Ibrutinib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24