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CAS 301693-70-9
4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylsulfinyl)phenyl)furan-3(2H)-one
Codes：POLM-016
Application context (from source-drug indications)
骨关节炎帕马考昔髋关节炎帕马考昔膝关节炎帕马考昔
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 帕马考昔Polmacoxib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(3-fluorophenyl)acetic acid→2-(3-fluorophenyl)acetyl chloride→methyl(phenyl)sulfane→2-(3-fluorophenyl)-1-(4-(methylthio)phenyl)ethan-1-one→2-bromo-2-methylpropanoyl cyanide→4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one→4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylsulfinyl)phenyl)furan-3(2H)-one→((4-(3-(3-fluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)phenyl)sulfonyl)methyl acetate→sodium 4-(3-(3-fluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfinate
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