帕马考昔
Tier C — Watch / tradePolmacoxib
Targets：COX-2
Brand：Acelex
Indications (approved)：骨关节炎
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| POLM-001 | 115-19-5 | 2-methylbut-3-yn-2-ol |
| POLM-002 | 3446-89-7 | 4-(methylthio)benzaldehyde |
| POLM-003 | 301698-93-1 | 4-methyl-1-(4-(methylthio)phenyl)pent-2-yne-1,4-diol |
| POLM-004 | 301698-94-2 | 4-hydroxy-4-methyl-1-(4-(methylthio)phenyl)pent-2-yn-1-one |
| POLM-005 | 301698-95-3 | 2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one |
| POLM-006 | 301699-00-3 | 2,2-dimethyl-5-(4-(methylsulfinyl)phenyl)furan-3(2H)-one |
| POLM-007 | 301699-01-4 | 4-iodo-2,2-dimethyl-5-(4-(methylsulfinyl)phenyl)furan-3(2H)-one |
| POLM-008 | 301699-02-5 | 4-(3-iodo-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide |
| POLM-009 | 768-35-4 | (3-fluorophenyl)boronic acid |
| Code | CAS No. | Intermediate |
|---|---|---|
| POLM-010 | 331-25-9 | 2-(3-fluorophenyl)acetic acid |
| POLM-011 | 458-04-8 | 2-(3-fluorophenyl)acetyl chloride |
| POLM-012 | 100-68-5 | methyl(phenyl)sulfane |
| POLM-013 | 301699-27-4 | 2-(3-fluorophenyl)-1-(4-(methylthio)phenyl)ethan-1-one |
| POLM-014 | 55106-47-3 | 2-bromo-2-methylpropanoyl cyanide |
| POLM-015 | 301693-50-5 | 4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one |
| POLM-016 | 301693-70-9 | 4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylsulfinyl)phenyl)furan-3(2H)-one |
| POLM-017 | 1778703-66-4 | ((4-(3-(3-fluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)phenyl)sulfonyl)methyl acetate |
| POLM-018 | 1778703-67-5 | sodium 4-(3-(3-fluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfinate |
Frequently asked questions
What are the approved indications of Polmacoxib?
Approved indications include: 骨关节炎.
When does the Polmacoxib patent expire?
No public expiry year is available for Polmacoxib yet; this page updates once verified.
How many synthesis routes are recorded for Polmacoxib?
2 synthesis routes are recorded; the shortest is 7 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Polmacoxib intermediates?
All intermediates in Polmacoxib routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Polmacoxib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24