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CAS 301698-93-1
4-methyl-1-(4-(methylthio)phenyl)pent-2-yne-1,4-diol
Codes：POLM-003
Application context (from source-drug indications)
骨关节炎帕马考昔髋关节炎帕马考昔膝关节炎帕马考昔
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 帕马考昔Polmacoxib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-methylbut-3-yn-2-ol→4-(methylthio)benzaldehyde→4-methyl-1-(4-(methylthio)phenyl)pent-2-yne-1,4-diol→4-hydroxy-4-methyl-1-(4-(methylthio)phenyl)pent-2-yn-1-one→2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one→2,2-dimethyl-5-(4-(methylsulfinyl)phenyl)furan-3(2H)-one→4-iodo-2,2-dimethyl-5-(4-(methylsulfinyl)phenyl)furan-3(2H)-one→4-(3-iodo-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzenesulfonamide→(3-fluorophenyl)boronic acid
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