CAS 3131-63-3

2-ethylbenzofuran

Codes: BENZB-008

Application context (from source-drug indications)

GoutBenzbromaroneHyperuricaemiaBenzbromaroneIdiopathic pulmonary arterial hypertensionBenzbromarone

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Benzbromarone	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

BenzbromaroneOptimised routesteps: 4total yield: 9.8 g (Benzbromarone)

3,5-Dibromo-4-hydroxybenzoic acid→3,5-Dibromo-4-[(oxan-2-yl)oxy]benzoic acid→3,5-Dibromo-4-[(oxan-2-yl)oxy]benzoyl chloride→2-ethylbenzofuran→[3,5-Dibromo-4-[(oxan-2-yl)oxy]phenyl](2-ethyl-1-benzofuran-3-yl)methanone

BenzbromaroneOptimised routesteps: 4total yield: /

2-ethylbenzofuran→4-methoxybenzoyl chloride→(2-ethylbenzofuran-3-yl)(4-methoxyphenyl)methanone→(2-ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone→3,4-dihydro-2H-pyran-2-carbaldehyde→1-(4-methoxyphenyl)pentane-1,3-dione

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