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CAS 320407-92-9
4-(bromomethyl)-2-chloro-1-methoxybenzene
Codes：AVAN-017
Application context (from source-drug indications)
勃起功能障碍阿伐那非
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 阿伐那非Avanafil | Tier C — Watch / trade | 2028 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-pyrrolidin-2-ylmethanol→4-(bromomethyl)-2-chloro-1-methoxybenzene→4-aminopyrimidin-2(1H)-one→4-((3-chloro-4-methoxybenzyl)amino)pyrimidin-2(1H)-one→(S)-(1-(4-((3-chloro-4-methoxybenzyl)amino)pyrimidin-2-yl)pyrrolidin-2-yl)methanol→N-(pyrimidin-2-ylmethyl)formamide
(S)-pyrrolidin-2-ylmethanol→4-(bromomethyl)-2-chloro-1-methoxybenzene→4-aminopyrimidin-2(1H)-one→4-((3-chloro-4-methoxybenzyl)amino)pyrimidin-2(1H)-one→N-(pyrimidin-2-ylmethyl)formamide→4-((3-chloro-4-methoxybenzyl)amino)-2-oxo-N-(pyrimidin-2-ylmethyl)-1,2-dihydropyrimidine-5-carboxamide
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