CAS 339-59-3

4-(trifluoromethyl)benzohydrazide

Codes：TECO-004

Application context (from source-drug indications)

猴痘病毒感染Tecovirimat牛痘Tecovirimat天花感染Tecovirimat痘病毒感染Tecovirimat牛痘病Tecovirimat正痘病毒感染Tecovirimat

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
TecovirimatTecovirimat	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Tecovirimat原研路线steps: 2total yield: 152.00 mg (Tecovirimat)

cyclohepta-1,3,5-triene→furan-2,5-dione→(3aR,4R,4aR,5aS,6S,6aS)-4,4a,5,5a,6,6a-hexahydro-1H-4,6-ethenocyclopropa[f]isobenzofuran-1,3(3aH)-dione→4-(trifluoromethyl)benzohydrazide

Tecovirimat优化路线steps: 2total yield: 0.84 g (Tecovirimat)

cyclohepta-1,3,5-triene→furan-2,5-dione→4-(trifluoromethyl)benzohydrazide→N-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-4-(trifluoromethyl)benzamide

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