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CAS 343926-69-2
4-bromopyrimidin-2-amine
Codes：RILP-014
Application context (from source-drug indications)
HIV感染盐酸利匹韦林肝功能衰退盐酸利匹韦林获得性免疫缺损综合征盐酸利匹韦林避孕行为盐酸利匹韦林
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 盐酸利匹韦林Rilpivirine Hydrochloride | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-bromo-2,6-dimethylaniline→4-bromopyrimidin-2-amine→tert-butyl (4-bromopyrimidin-2-yl)carbamate→tert-butyl (4-((4-bromo-2-methylphenyl)amino)pyrimidin-2-yl)carbamate→N4-(4-bromo-2,6-dimethylphenyl)pyrimidine-2,4-diamine→(E)-3-(4-((2-aminopyrimidin-4-yl)amino)-3,5-dimethylphenyl)acrylonitrile→4-bromobenzonitrile
4-bromopyrimidin-2-amine→(E)-3-(4-((2-aminopyrimidin-4-yl)amino)-3,5-dimethylphenyl)acrylonitrile→4-bromobenzonitrile→methyl 4-amino-3,5-dimethylbenzoate→methyl 4-((2-((tert-butoxycarbonyl)amino)pyrimidin-4-yl)amino)-3,5-dimethylbenzoate→methyl 4-((2-aminopyrimidin-4-yl)amino)-3,5-dimethylbenzoate→(4-((2-aminopyrimidin-4-yl)amino)-3,5-dimethylphenyl)methanol→4-((2-aminopyrimidin-4-yl)amino)-3,5-dimethylbenzaldehyde→(cyanomethyl)triphenylphosphonium chloride
Intermediates available on this site
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