盐酸利匹韦林
Tier B — Position earlyRilpivirine Hydrochloride
Targets：RT
Brand：Edurant、Rekambys、EDURANT® PED
Indications (approved)：HIV感染
Regional status
Synthetic routes & intermediates6 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| RILP-001 | 244768-32-9 | 4-((4-chloropyrimidin-2-yl)amino)benzonitrile |
| RILP-002 | 3095-47-4 | ethyl 4-amino-3,5-dimethylbenzoate |
| RILP-003 | 708254-90-4 | ethyl 4-((2-((4-cyanophenyl)amino)pyrimidin-4-yl)amino)-3,5-dimethylbenzoate |
| RILP-004 | 823786-21-6 | 4-((4-((4-(hydroxymethyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile |
| RILP-005 | 500293-29-8 | 4-((4-((4-formyl-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile |
| Code | CAS No. | Intermediate |
|---|---|---|
| RILP-001 | 244768-32-9 | 4-((4-chloropyrimidin-2-yl)amino)benzonitrile |
| RILP-006 | 24596-19-8 | 4-bromo-2,6-dimethylaniline |
| RILP-007 | 374067-85-3 | 4-((4-((4-bromo-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile |
| Code | CAS No. | Intermediate |
|---|---|---|
| RILP-001 | 244768-32-9 | 4-((4-chloropyrimidin-2-yl)amino)benzonitrile |
| RILP-008 | 16947-63-0 | 2,6-dimethyl-4-nitroaniline |
| RILP-009 | 86955-76-2 | benzyl (2,6-dimethyl-4-nitrophenyl)carbamate |
| RILP-010 | 1403891-82-6 | benzyl (4-amino-2,6-dimethylphenyl)carbamate hydrochloride |
| RILP-011 | 1403891-71-3 | 4-(((benzyloxy)carbonyl)amino)-3,5-dimethylbenzenediazonium tetrafluoroborate |
| RILP-012 | 1403891-74-6 | benzyl (E)-(4-(2-cyanovinyl)-2,6-dimethylphenyl)carbamate |
| RILP-013 | 661489-23-2 | (E)-3-(4-amino-3,5-dimethylphenyl)acrylonitrile hydrochloride |
| Code | CAS No. | Intermediate |
|---|---|---|
| RILP-006 | 24596-19-8 | 4-bromo-2,6-dimethylaniline |
| RILP-014 | 343926-69-2 | 4-bromopyrimidin-2-amine |
| RILP-015 | 1478365-70-6 | tert-butyl (4-bromopyrimidin-2-yl)carbamate |
| RILP-016 | 1446690-22-7 | tert-butyl (4-((4-bromo-2-methylphenyl)amino)pyrimidin-2-yl)carbamate |
| RILP-017 | 1446690-21-6 | N4-(4-bromo-2,6-dimethylphenyl)pyrimidine-2,4-diamine |
| RILP-018 | 1446439-47-9 | (E)-3-(4-((2-aminopyrimidin-4-yl)amino)-3,5-dimethylphenyl)acrylonitrile |
| RILP-019 | 623-00-7 | 4-bromobenzonitrile |
| Code | CAS No. | Intermediate |
|---|---|---|
| RILP-014 | 343926-69-2 | 4-bromopyrimidin-2-amine |
| RILP-018 | 1446439-47-9 | (E)-3-(4-((2-aminopyrimidin-4-yl)amino)-3,5-dimethylphenyl)acrylonitrile |
| RILP-019 | 623-00-7 | 4-bromobenzonitrile |
| RILP-020 | 3095-48-5 | methyl 4-amino-3,5-dimethylbenzoate |
| RILP-021 | - | methyl 4-((2-((tert-butoxycarbonyl)amino)pyrimidin-4-yl)amino)-3,5-dimethylbenzoate |
| RILP-022 | 1446701-97-8 | methyl 4-((2-aminopyrimidin-4-yl)amino)-3,5-dimethylbenzoate |
| RILP-023 | 1446701-99-0 | (4-((2-aminopyrimidin-4-yl)amino)-3,5-dimethylphenyl)methanol |
| RILP-024 | 1446702-00-6 | 4-((2-aminopyrimidin-4-yl)amino)-3,5-dimethylbenzaldehyde |
| RILP-025 | 4336-70-3 | (cyanomethyl)triphenylphosphonium chloride |
| Code | CAS No. | Intermediate |
|---|---|---|
| RILP-013 | 661489-23-2 | (E)-3-(4-amino-3,5-dimethylphenyl)acrylonitrile hydrochloride |
| RILP-026 | 3934-20-1Available | 2,4-dichloropyrimidine |
| RILP-027 | 1538550-43-4 | (E)-3-(4-((2-chloropyrimidin-4-yl)amino)-3,5-dimethylphenyl)acrylonitrile |
| RILP-028 | 873-74-5Available | 4-aminobenzonitrile |
Frequently asked questions
What are the approved indications of Rilpivirine Hydrochloride?
Approved indications include: HIV感染.
When does the Rilpivirine Hydrochloride patent expire?
No public expiry year is available for Rilpivirine Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Rilpivirine Hydrochloride?
6 synthesis routes are recorded; the shortest is 2 steps with 35 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Rilpivirine Hydrochloride intermediates?
2 intermediate CAS of Rilpivirine Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Rilpivirine Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24