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CAS 34654-80-3

6-(3-Hydroxypropyl)-1,3-dimethyluracil6-(3-Hydroxypropylamino)-1,3-dimethyluracil

Codes: Urapidil-005

Application context (from source-drug indications)

HypertensionUrapidil hydrochloride

Source drugs (routes using this intermediate)

DrugTierExpiry
Urapidil hydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Urapidil hydrochlorideOptimised routesteps: 1total yield: 105.24g(Urapidil-005)
6-Hydroxy-1,3-dimethylpyrimidine-2,4(1H,3H)-dione→1-Amino-3-propanol→6-(3-Hydroxypropylamino)-1,3-dimethyluracil
Urapidil hydrochlorideOptimised routesteps: 3total yield: 9.1g(Urapidil (Free))
6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione→1,3-Epoxypropane→6-(3-Hydroxypropylamino)-1,3-dimethyluracil→3-[(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino]propyl 4-methylbenzene-1-sulfonate→1-(2-Methoxyphenyl)piperazine

Intermediates available on this site

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