Urapidil hydrochloride

Tier C — Watch / trade

Originator

2000

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：Adrenoceptors

Indications (approved)：Hypertension

Regional status

China

Approved

2000-01-01

Japan

Synthetic routes & intermediates8 routes

Originator routes × 0Optimised (non-patent) × 7Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 7 · Total yield /

Urapidil-0016642-31-5Urapidil-0026972-27-6Urapidil-003156-87-6Urapidil-0046276-54-6Urapidil-00534654-80-3Urapidil-00634654-81-4Urapidil-00735386-24-4Urapidil-0085464-78-8Urapidil-00920529-23-1Urapidil-0101990-05-01Urapidil-011—Urapidil-012110-85-0API · Urapidil hydrochloride

Code	CAS No.	Intermediate
Urapidil-001	6642-31-5	6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
Urapidil-002	6972-27-6	6-Chloro-1,3-dimethyluracil
Urapidil-003	156-87-6	3-Aminopropan-1-ol
Urapidil-004	6276-54-6	3-Chloropropylamine hydrochloride
Urapidil-005	34654-80-3	6-(3-Hydroxypropyl)-1,3-dimethyluracil
Urapidil-006	34654-81-4	6-[(3-Chloropropyl)amino]-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
Urapidil-007	35386-24-4	1-(2-Methoxyphenyl)piperazine
Urapidil-008	5464-78-8	1-(2-Methoxyphenyl)piperazine hydrochloride
Urapidil-009	20529-23-1	1-(3-Aminopropyl)-4-(2-methoxyphenyl)piperazine
Urapidil-010	1990-05-01	Pyrocatechol monomethyl ether
Urapidil-011	-	2-methoxyphenyl methanesulfonate
Urapidil-012	110-85-0 Available	Diethylenediamine

OptimisedRoute 2Steps 3 · Total yield /

Urapidil-0085464-78-8Urapidil-00920529-23-1Urapidil-01390-04-0Urapidil-0141011513-93-1Urapidil-015109-70-6Urapidil-01621279-77-6API · Urapidil hydrochloride

Code	CAS No.	Intermediate
Urapidil-008	5464-78-8	1-(2-Methoxyphenyl)piperazine hydrochloride
Urapidil-009	20529-23-1	1-(3-Aminopropyl)-4-(2-methoxyphenyl)piperazine
Urapidil-013	90-04-0	o-Anisidine
Urapidil-014	1011513-93-1	bis(2-chloroethyl)amine hydrochloride
Urapidil-015	109-70-6	1-bromo-3-chloropropane
Urapidil-016	21279-77-6	Piperazine,1-(3-chloropropyl)-4-(2-methoxyphenyl)-

OptimisedRoute 4Steps 1 · Total yield 105.24g(Urapidil-005)

Urapidil-020882872-13-1Urapidil-003156-87-6Urapidil-00534654-80-3API · Urapidil hydrochloride

Code	CAS No.	Intermediate
Urapidil-020	882872-13-1	6-Hydroxy-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
Urapidil-003	156-87-6	1-Amino-3-propanol
Urapidil-005	34654-80-3	6-(3-Hydroxypropylamino)-1,3-dimethyluracil

OptimisedRoute 5Steps 1 · Total yield 58.9g(Urapidil-022)

Urapidil-00735386-24-4Urapidil-021107-13-1Urapidil-02221103-25-3API · Urapidil hydrochloride

Code	CAS No.	Intermediate
Urapidil-007	35386-24-4	1-(2-Methoxyphenyl)piperazine
Urapidil-021	107-13-1	2-Propenonitrile
Urapidil-022	21103-25-3	3-[4-(2-Methoxyphenyl)piperazin-1-yl]propanenitrile

OptimisedRoute 6Steps 2 · Total yield /

Urapidil-01796-31-1Urapidil-023372-09-8Urapidil-02439615-79-7Urapidil-0016642-31-5API · Urapidil hydrochloride

Code	CAS No.	Intermediate
Urapidil-017	96-31-1	1,3-Dimethylurea
Urapidil-023	372-09-8 Available	Cyanoacetic acid
Urapidil-024	39615-79-7	Acetamide,2-cyano-N-methyl-N-[(methylamino)carbonyl]-
Urapidil-001	6642-31-5	6-Amino-1,3-dimethyluracil

OptimisedRoute 7Steps 3 · Total yield 9.1g(Urapidil (Free))

Urapidil-0016642-31-5Urapidil-025503-30-0Urapidil-00534654-80-3Urapidil-026—Urapidil-00735386-24-4API · Urapidil hydrochloride

Code	CAS No.	Intermediate
Urapidil-001	6642-31-5	6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
Urapidil-025	503-30-0	1,3-Epoxypropane
Urapidil-005	34654-80-3	6-(3-Hydroxypropylamino)-1,3-dimethyluracil
Urapidil-026	-	3-[(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino]propyl 4-methylbenzene-1-sulfonate
Urapidil-007	35386-24-4	1-(2-Methoxyphenyl)piperazine

OptimisedRoute 8Steps 3 · Total yield 31.69g(Urapidil-030)

Urapidil-0273303-84-2Urapidil-0085464-78-8Urapidil-028—Urapidil-029—Urapidil-030—API · Urapidil hydrochloride

Code	CAS No.	Intermediate
Urapidil-027	3303-84-2	3-[(2-Methylpropan-2-yl)oxycarbonylamino]propanoic acid
Urapidil-008	5464-78-8	1-(2-Methoxyphenyl)piperazine hydrochloride
Urapidil-028	-	tert-Butyl [3-[4-(2-methoxyphenyl)piperazin-1-yl]-3-oxopropyl]carbamate
Urapidil-029	-	1-(N-Boc-3-aminopropyl)-4-(2-methoxyphenyl)piperazine
Urapidil-030	-	1-(3-Aminopropyl)-4-(2-methoxyphenyl)piperazine trihydrochloride

ProcessRoute 3Steps 2 · Total yield 58.5kg(Urapidil-002)

Urapidil-01796-31-1Urapidil-018108-59-8Urapidil-019769-42-6Urapidil-0026972-27-6API · Urapidil hydrochloride

Code	CAS No.	Intermediate
Urapidil-017	96-31-1	1,3-Dimethylurea
Urapidil-018	108-59-8 Available	1,3-Dimethyl propanedioate
Urapidil-019	769-42-6	1,3-Dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione
Urapidil-002	6972-27-6	6-Chloro-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Frequently asked questions

What are the approved indications of Urapidil hydrochloride?

Approved indications include: Hypertension.

When does the Urapidil hydrochloride patent expire?

No public expiry year is available for Urapidil hydrochloride yet; this page updates once verified.

How many synthesis routes are recorded for Urapidil hydrochloride?

8 synthesis routes are recorded; the shortest is 1 steps with 105.24g(Urapidil-005) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Urapidil hydrochloride intermediates?

3 intermediate CAS of Urapidil hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Urapidil hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-27