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CAS 351227-63-9

di-tert-butyl ((((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl)oxy)methyl) phosphate

Codes:FOSR-003

Application context (from source-drug indications)

甲癣Fosravuconazole L-Lysine Ethanolate美洲锥虫病Fosravuconazole L-Lysine Ethanolate

Source drugs (routes using this intermediate)

DrugTierExpiry
Fosravuconazole L-Lysine EthanolateFosravuconazole L-Lysine EthanolateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

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Fosravuconazole L-Lysine Ethanolate原研路线steps: 2total yield: 1.5 g
4-(2-((2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile→di-tert-butyl (chloromethyl) phosphate→di-tert-butyl ((((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl)oxy)methyl) phosphate

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