CAS 229625-50-7

di-tert-butyl (chloromethyl) phosphate

Codes：FOST-004、FOSR-002

Application context (from source-drug indications)

特发性血小板减少性紫癜福他替尼二钠六水合物血小板减少福他替尼二钠六水合物病毒性肺炎福他替尼二钠六水合物肺炎福他替尼二钠六水合物新型冠状病毒感染福他替尼二钠六水合物严重急性呼吸系统综合征福他替尼二钠六水合物甲癣Fosravuconazole L-Lysine Ethanolate美洲锥虫病Fosravuconazole L-Lysine Ethanolate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
福他替尼二钠六水合物Fostamatinib disodium hexahydrate	Tier C — Watch / trade	-
Fosravuconazole L-Lysine EthanolateFosravuconazole L-Lysine Ethanolate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

福他替尼二钠六水合物原研路线steps: 4total yield: 8.18

6-[(2-chloro-5-fluoropyrimidin-4-yl)amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one→3,4,5-trimethoxyaniline→6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one→di-tert-butyl (chloromethyl) phosphate→di-tert-butyl ((6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl) phosphate→(6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl dihydrogen phosphate

Fosravuconazole L-Lysine Ethanolate原研路线steps: 2total yield: 1.5 g

4-(2-((2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile→di-tert-butyl (chloromethyl) phosphate→di-tert-butyl ((((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl)oxy)methyl) phosphate

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	6-Amino-2,2-dimethyl-2H-pyrido[3,2-B][1,4]oxazin-3(4H)-one Pharmaceutical Intermediates	询价	询价	询价	—

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