CAS 357425-93-5

2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepin-3-ium 4-methylbenzenesulfonate

Codes：VARE-016

Application context (from source-drug indications)

尼古丁依赖酒石酸伐尼克兰吸烟戒断酒石酸伐尼克兰戒烟酒石酸伐尼克兰减少吸烟酒石酸伐尼克兰大麻依赖酒石酸伐尼克兰雾化酒石酸伐尼克兰

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
酒石酸伐尼克兰Varenicline Tartrate	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

酒石酸伐尼克兰优化路线steps: 6total yield: /

2,2,2-trifluoro-1-(1,2,4,5-tetrahydro-3H-1,5-methanobenzo[d]azepin-3-yl)ethan-1-one→2-(2-bromophenyl)acetonitrile→methyl (E)-3-methoxyacrylate→methyl (Z)-4-(2-bromophenyl)-4-cyanobut-3-enoate→sodium (Z)-(3-cyano-1H-inden-1-ylidene)(methoxy)methanolate→methyl 3-(aminomethyl)-2,3-dihydro-1H-indene-1-carboxylate→1,3,4,5-tetrahydro-2H-1,5-methanobenzo[d]azepin-2-one→2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepin-3-ium 4-methylbenzenesulfonate

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	1,4-DIHYDRO-1,4-METHANONAPHTHALENE Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	2,3,4,5-Tetrahydro-7,8-dinitro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	2,3,4,5-Tetrahydro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine-7,8-diamine Pharmaceutical Intermediates	询价	询价	询价	—

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