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CAS 369-34-6
1,2-difluoro-4-nitrobenzene
Codes: LINE-001
Application context (from source-drug indications)
非复杂性皮肤和皮肤结构感染LinezolidPneumoniaLinezolidComplicated skin and skin structure infectionLinezolidBacteraemiaLinezolidBacterial infectionLinezolidHealthcare-associated pneumoniaLinezolid
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Linezolid | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,2-difluoro-4-nitrobenzene→morpholine→4-(2-fluoro-4-nitrophenyl)morpholine→3-fluoro-4-morpholinoaniline→benzyl (3-fluoro-4-morpholinophenyl)carbamatebenzyl (3-fluoro-4-morpholinophenyl)carbamate→(R)-oxiran-2-ylmethyl butyrate→(R)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)oxazolidin-2-one→(R)-(3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate→(R)-5-(azidomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one
1,2-difluoro-4-nitrobenzene→morpholine→4-(2-fluoro-4-nitrophenyl)morpholine→3-fluoro-4-morpholinoaniline→(R)-5-(azidomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one→4-(2-fluoro-4-isocyanatophenyl)morpholine→(R)-2-(chloromethyl)oxirane→(R)-5-(chloromethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one
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