CAS 3731-53-1

pyridin-4-ylmethanamine

Codes：APAT-006

Application context (from source-drug indications)

乳腺癌甲磺酸阿帕替尼胃癌甲磺酸阿帕替尼非小细胞肺癌甲磺酸阿帕替尼卵巢癌甲磺酸阿帕替尼腹膜癌甲磺酸阿帕替尼卵巢上皮癌甲磺酸阿帕替尼

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
甲磺酸阿帕替尼Apatinib Mesylate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

甲磺酸阿帕替尼原研路线steps: 5total yield: 161.5 g

1-phenylcyclopentanecarbonitrile→1-(4-nitrophenyl)cyclopentanecarbonitrile→1-(4-aminophenyl)cyclopentanecarbonitrile→2-chloronicotinoyl chloride→2-chloro-N-(4-(1-cyanocyclopentyl)phenyl)nicotinamide→pyridin-4-ylmethanamine

Intermediates available on this site

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