CAS 38254-49-8

1-bromo-2-methylpropan-2-ol

Codes：SELP-024

Application context (from source-drug indications)

实体瘤塞普替尼甲状腺髓样癌塞普替尼非小细胞肺癌塞普替尼甲状腺瘤塞普替尼

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
塞普替尼Selpercatinib	Tier C — Watch / trade	2032

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

塞普替尼优化路线steps: 2total yield: 41.4 g (Selpercatinib)

6-methoxynicotinaldehyde→4-(6-(3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)-6-hydroxypyrazolo[1,5-a]pyridine-3-carbonitrile→1-bromo-2-methylpropan-2-ol→4-(6-(3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile

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