塞普替尼
Tier C — Watch / tradeSelpercatinib · all drugs expiring in 2032 →
Targets：RET、VEGFR3、VEGFR1、FGFR2、FGFR3、FGFR1
Brand：睿妥、Retsevmo、Retevmo
Indications (approved)：实体瘤、甲状腺髓样癌、非小细胞肺癌、甲状腺瘤
Regional status
Synthetic routes & intermediates3 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| SELP-018 | 2222653-74-7 | 4-(6-fluoropyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile |
| SELP-019 | 869494-16-6Available | tert-butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate |
| SELP-020 | 2222755-94-2 | tert-butyl 3-(5-(3-cyano-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridin-4-yl)pyridin-2-yl)-3,6-diazabicyclo[3.1.1]heptane-6-carboxylate |
| SELP-021 | 2222752-06-7 | 4-(6-(3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile |
| SELP-022 | 65873-72-5Available | 6-methoxynicotinaldehyde |
| SELP-001 | 36016-38-3 | tert-butyl hydroxycarbamate |
| SELP-002 | 773-64-8 | 2,4,6-trimethylbenzenesulfonyl chloride |
| SELP-003 | 36016-39-4 | tert-butyl ((mesitylsulfonyl)oxy)carbamate |
| SELP-004 | 36016-40-7 | O-(mesitylsulfonyl)hydroxylamine |
| SELP-005 | 50720-12-2 | 3-bromo-5-methoxypyridine |
| SELP-006 | 1207839-87-9 | 1-amino-3-bromo-5-methoxypyridin-1-ium 2,4,6-trimethylbenzenesulfonate |
| SELP-007 | 623-47-2 | ethyl propiolate |
| SELP-008 | 1207557-35-4 | ethyl 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carboxylate |
| SELP-009 | 1416439-70-7 | ethyl 4-bromo-6-methoxypyrazolo[1,5-a]pyridine-3-carboxylate |
| SELP-010 | 1207839-86-8 | 4-bromo-6-methoxypyrazolo[1,5-a]pyridine |
| SELP-011 | 2068065-03-0 | 4-bromo-6-methoxypyrazolo[1,5-a]pyridine-3-carbaldehyde |
| SELP-012 | 2068065-04-1 | (E)-4-bromo-6-methoxypyrazolo[1,5-a]pyridine-3-carbaldehyde oxime |
| SELP-013 | 1822680-43-2 | 4-bromo-6-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile |
| SELP-014 | 2068065-05-2 | 4-bromo-6-hydroxypyrazolo[1,5-a]pyridine-3-carbonitrile |
| SELP-015 | 558-30-5 | 2,2-dimethyloxirane |
| SELP-016 | 2222653-73-6 | 4-bromo-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile |
| SELP-017 | 444120-95-0Available | 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine |
| Code | CAS No. | Intermediate |
|---|---|---|
| SELP-022 | 65873-72-5Available | 6-methoxynicotinaldehyde |
| SELP-023 | 2222756-36-5 | 4-(6-(3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)-6-hydroxypyrazolo[1,5-a]pyridine-3-carbonitrile |
| SELP-024 | 38254-49-8 | 1-bromo-2-methylpropan-2-ol |
| SELP-025 | 2222752-06-7 | 4-(6-(3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile |
| Code | CAS No. | Intermediate |
|---|---|---|
| SELP-015 | 558-30-5 | 2,2-dimethyloxirane |
| SELP-018 | 2222653-74-7 | 4-(6-fluoropyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile |
| SELP-026 | 2222654-09-1 | 4-(6-fluoropyridin-3-yl)-6-hydroxypyrazolo[1,5-a]pyridine-3-carbonitrile |
| SELP-027 | 2306275-33-0 | 6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptane |
Frequently asked questions
What are the approved indications of Selpercatinib?
Approved indications include: 实体瘤, 甲状腺髓样癌, 非小细胞肺癌, 甲状腺瘤.
When does the Selpercatinib patent expire?
Based on public sources, the Selpercatinib patent expires in 2032.
How many synthesis routes are recorded for Selpercatinib?
3 synthesis routes are recorded; the shortest is 2 steps with 41.4 g (Selpercatinib) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Selpercatinib intermediates?
3 intermediate CAS of Selpercatinib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Selpercatinib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24