CAS 38385-95-4

2-(piperidin-4-yl)-1H-benzo[d]imidazole

Codes：BALI-001、BALI-007

Application context (from source-drug indications)

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Source drugs (routes using this intermediate)

Drug	Tier	Expiry
比拉斯汀Bilastine	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

比拉斯汀原研路线steps: 3total yield: 3.5 g

2-(piperidin-4-yl)-1H-benzo[d]imidazole→4-(2-(4,5-dihydrooxazol-2-yl)propan-2-yl)phenethyl 4-methylbenzenesulfonate→2-(2-(4-(2-(4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,5-dihydrooxazole→2-(2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,5-dihydrooxazole

比拉斯汀优化路线steps: 8total yield: 1.84 g

benzene-1,2-diamine→piperidine-4-carboxylic acid→2-(piperidin-4-yl)-1H-benzo[d]imidazole→tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate→2-ethoxyethyl methanesulfonate→tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate→1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole→ethyl 2-methyl-2-(4-(2-((methylsulfonyl)oxy)ethyl)phenyl)propanoate→ethyl 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoate→2-(4-bromophenyl)ethan-1-ol→((1-ethoxy-2-methylprop-1-en-1-yl)oxy)trimethylsilane→ethyl 2-(4-(2-hydroxyethyl)phenyl)-2-methylpropanoate

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Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	2-Piperidin-4-yl-1H-benzoimidazole Pharmaceutical Intermediates	询价	询价	询价	—

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