Unibest 优贝德
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比拉斯汀

Tier C — Watch / trade

Bilastine

Faes Farma
Originator
2010
First approval
-
Expiry (public)
$0.11B ▲
Peak sales
化学药
Type

Targets：HRH1

Brand：Ilaxten、Bilanoa、Bitosen、Bilaxten、力敏能、Bilatex、Blexten

Indications (approved)：荨麻疹、过敏性鼻炎、皮炎、瘙痒症、湿疹、变应性结膜炎、常年性变应性鼻炎、季节性过敏性鼻炎

Regional status

US
无进展
2018-04-07
EU
批准上市
2010-01-01
China
批准上市
2023-06-21
Japan
批准上市
2016-09-28

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 3 · Total yield 3.5 g
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
BALI-00138385-95-4Available2-(piperidin-4-yl)-1H-benzo[d]imidazole
BALI-002-4-(2-(4,5-dihydrooxazol-2-yl)propan-2-yl)phenethyl 4-methylbenzenesulfonate
BALI-003-2-(2-(4-(2-(4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,5-dihydrooxazole
BALI-004-2-(2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,5-dihydrooxazole
OptimisedRoute 2Steps 8 · Total yield 1.84 g
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
BALI-00595-54-5Availablebenzene-1,2-diamine
BALI-006498-94-2Availablepiperidine-4-carboxylic acid
BALI-00738385-95-4Available2-(piperidin-4-yl)-1H-benzo[d]imidazole
BALI-008953071-73-3Availabletert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
BALI-00998139-68-5Available2-ethoxyethyl methanesulfonate
BALI-0101181267-36-6Availabletert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
BALI-011110963-63-8Available1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole
BALI-0121181267-34-4Availableethyl 2-methyl-2-(4-(2-((methylsulfonyl)oxy)ethyl)phenyl)propanoate
BALI-013202189-79-5Availableethyl 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoate
BALI-0144654-39-1Available2-(4-bromophenyl)ethan-1-ol
BALI-01531469-16-6Available((1-ethoxy-2-methylprop-1-en-1-yl)oxy)trimethylsilane
BALI-0161181267-31-1Availableethyl 2-(4-(2-hydroxyethyl)phenyl)-2-methylpropanoate
OptimisedRoute 3Steps 4 · Total yield 7 g
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
BALI-011110963-63-8Available1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole
BALI-013202189-79-5Availableethyl 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoate
BALI-01757625-74-8Availablemethyl 2-methyl-2-phenylpropanoate
BALI-01879-04-9Available2-chloroacetyl chloride
BALI-0191638785-19-9Availablemethyl 2-(4-(2-chloroacetyl)phenyl)-2-methylpropanoate
BALI-0201638785-20-2Availablemethyl 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)acetyl)phenyl)-2-methylpropanoate
OptimisedRoute 4Steps 5 · Total yield 0.466/g
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
BALI-0144654-39-1Available2-(4-bromophenyl)ethan-1-ol
BALI-01531469-16-6Available((1-ethoxy-2-methylprop-1-en-1-yl)oxy)trimethylsilane
BALI-0161181267-31-1Availableethyl 2-(4-(2-hydroxyethyl)phenyl)-2-methylpropanoate
BALI-021114369-15-2Available4-bromophenethyl methanesulfonate
BALI-0221126-09-6Availableethyl piperidine-4-carboxylate
BALI-023-ethyl 1-(2-(4-bromophenyl)-2-oxoethyl)piperidine-4-carboxylate fumarate
BALI-02495893-89-3AvailableN1-(2-ethoxyethyl)benzene-1,2-diamine
BALI-0251567835-74-8Available2-(1-(4-bromophenethyl)piperidin-4-yl)-1-(2-ethoxyethyl)-1H-benzo[d]imidazole
OptimisedRoute 5Steps 2 · Total yield /
Synthetic routes & intermediates Route 5
CodeCAS No.Intermediate
BALI-026-2-(2-(4-bromophenyl)propan-2-yl)-4,5-dihydrooxazole
BALI-027-2-(2-(4-(2-bromoethyl)phenyl)propan-2-yl)-4,5-dihydrooxazole
BALI-028-2-(4-(2-(4,5-dihydrooxazol-2-yl)propan-2-yl)phenyl)ethan-1-ol

Frequently asked questions

What are the approved indications of Bilastine?

Approved indications include: 荨麻疹, 过敏性鼻炎, 皮炎, 瘙痒症, 湿疹, 变应性结膜炎, 常年性变应性鼻炎, 季节性过敏性鼻炎.

When does the Bilastine patent expire?

No public expiry year is available for Bilastine yet; this page updates once verified.

How many synthesis routes are recorded for Bilastine?

5 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Bilastine intermediates?

20 intermediate CAS of Bilastine are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Bilastine intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24