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CAS 438056-69-0
4-(4-aminophenyl)morpholin-3-one
Codes：RIVA-008
Application context (from source-drug indications)
肺栓塞利伐沙班中风利伐沙班先天性心脏缺损利伐沙班血栓形成利伐沙班静脉血栓栓塞利伐沙班冠状动脉疾病利伐沙班
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 利伐沙班Rivaroxaban | Tier A — Act now | 2026 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-aminoethan-1-ol→2-chloroacetyl chloride→2-(2-chloroacetamido)ethyl 2-chloroacetate→2-chloro-N-(2-hydroxyethyl)acetamide→morpholin-3-one→1-fluoro-4-nitrobenzene→4-(4-nitrophenyl)morpholin-3-one→4-(4-aminophenyl)morpholin-3-one→(S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione→(R)-2-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione→(S)-2-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione→(S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one oxalate→5-chlorothiophene-2-carbonyl chloride
4-(4-aminophenyl)morpholin-3-one→5-chlorothiophene-2-carbonyl chloride→5-chlorothiophene-2-carbaldehyde→5-chlorothiophene-2-carboxylic acid→(S)-3-aminopropane-1,2-diol hydrochloride→(S)-5-chloro-N-(2,3-dihydroxypropyl)thiophene-2-carboxamide→(S)-N-(3-bromo-2-hydroxypropyl)-5-chlorothiophene-2-carboxamide→(R)-5-chloro-N-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide
2-chloroacetyl chloride→4-(4-nitrophenyl)morpholin-3-one→4-(4-aminophenyl)morpholin-3-one→5-chlorothiophene-2-carbonyl chloride→2-(phenylamino)ethan-1-ol→4-phenylmorpholin-3-one→benzyl carbonochloridate→benzyl (4-(3-oxomorpholino)phenyl)carbamate→(R)-oxiran-2-ylmethyl butyrate→(R)-4-(4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(R)-(2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl methanesulfonate→2-methylpropan-2-amine→(S)-4-(4-(5-((tert-butylamino)methyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(S)-N-(tert-butyl)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
4-(4-aminophenyl)morpholin-3-one→5-chlorothiophene-2-carbonyl chloride→(R)-4-(4-(5-(hydroxymethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(S)-3-(benzyloxy)-2-hydroxypropyl 4-methylbenzenesulfonate→(S)-1-(benzyloxy)-3-(tosyloxy)propan-2-yl acetate→(R)-1-(benzyloxy)-3-((4-(3-oxomorpholino)phenyl)amino)propan-2-yl acetate→(R)-1-(benzyloxy)-3-((chlorocarbonyl)(4-(3-oxomorpholino)phenyl)amino)propan-2-yl acetate→(R)-4-(4-(5-((benzyloxy)methyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(R)-(2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl 4-methylbenzenesulfonate→(S)-4-(4-(5-((benzylamino)methyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(S)-N-benzyl-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
4-(4-aminophenyl)morpholin-3-one→5-chlorothiophene-2-carbaldehyde→(S)-2-(chloromethyl)oxirane→(S)-1-azido-3-chloropropan-2-ol→(S)-2-(azidomethyl)oxirane→(R)-4-(4-((3-azido-2-hydroxypropyl)amino)phenyl)morpholin-3-one→(R)-4-(4-(5-(azidomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one→(S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one
Intermediates available on this site
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| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 4-(4-Aminophenyl)morpholin -3-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
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