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CAS 4394-85-8
morpholine-4-carbaldehyde
Codes：PEMIGA-008、VEMF-028
Application context (from source-drug indications)
骨髓瘤佩米替尼淋巴瘤佩米替尼胆管癌佩米替尼胆管上皮癌佩米替尼胆道癌佩米替尼Erdheim-Chester病维罗非尼黑色素瘤维罗非尼组织细胞增生维罗非尼郎格罕细胞组织细胞增生症维罗非尼非霍奇金淋巴瘤维罗非尼肝胚细胞瘤维罗非尼
Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1H-pyrrolo[2,3-b]pyridine→1H-pyrrolo[2,3-b]pyridine 7-oxide→4-chloro-1H-pyrrolo[2,3-b]pyridine→4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine→4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde→4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde→4-chloro-5-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine→morpholine-4-carbaldehyde→4-chloro-5-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde→4-((4-chloro-5-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)methyl)morpholine→4-chloro-2-(morpholinomethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde→2,6-difluoro-3,5-dimethoxyaniline→N-((4-chloro-2-(morpholinomethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)-2,6-difluoro-3,5-dimethoxyaniline→isocyanatoethane→1-((4-chloro-2-(morpholinomethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)-1-(2,6-difluoro-3,5-dimethoxyphenyl)-3-ethylurea→3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-7-(phenylsulfonyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one→2,3,4,5,6-pentafluorobenzoic acid→methyl 2,3,4,5,6-pentafluorobenzoate→methyl 4-(benzylamino)-2,3,5,6-tetrafluorobenzoate→4-(benzylamino)-3,5-difluoro-2,6-dimethoxybenzoic acid→N-benzyl-2,6-difluoro-3,5-dimethoxyaniline→Pemigatinib
2,4-difluoroaniline→propane-1-sulfonyl chloride→5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine→N-(2,4-difluorophenyl)propane-1-sulfonamide→morpholine-4-carbaldehyde→N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide→N-(3-((5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)(hydroxy)methyl)-2,4-difluorophenyl)propane-1-sulfonamide
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