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维罗非尼
Tier C — Watch / tradeVemurafenib
第一三共株式会社
Originator
2011
First approval
-
Expiry (public)
$0.38B ▲
Peak sales
化学药
Type
Targets：B-raf
Brand：佐博伏、Zelboraf
Indications (approved)：Erdheim-Chester病、黑色素瘤
Regional status
US
批准上市
2011-08-17
EU
批准上市
2012-02-17
China
批准上市
2017-03-10
Japan
批准上市
2014-12-26
Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 4Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 6 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| VEMF-001 | 367-25-9 | 2,4-difluoroaniline |
| VEMF-002 | 918523-44-1 | benzyl 3-amino-2,6-difluorobenzoate |
| VEMF-003 | 10147-36-1 | propane-1-sulfonyl chloride |
| VEMF-004 | 918523-45-2 | benzyl 2,6-difluoro-3-(propylsulfonamido)benzoate |
| VEMF-005 | 1103234-56-5 | 2,6-difluoro-3-(propylsulfonamido)benzoic acid |
| VEMF-006 | 1186194-32-0 | 2,6-difluoro-3-(propylsulfonamido)benzoyl chloride |
| VEMF-007 | 183208-35-7Available | 5-bromo-1H-pyrrolo[2,3-b]pyridine |
| VEMF-008 | 918504-27-5 | N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide |
| VEMF-009 | 1679-18-1Available | (4-chlorophenyl)boronic acid |
OptimisedRoute 2Steps 4 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| VEMF-005 | 1103234-56-5 | 2,6-difluoro-3-(propylsulfonamido)benzoic acid |
| VEMF-009 | 1679-18-1Available | (4-chlorophenyl)boronic acid |
| VEMF-010 | 1072-97-5 | 5-bromopyridin-2-amine |
| VEMF-011 | 84596-08-7 | 5-(4-chlorophenyl)pyridin-2-amine |
| VEMF-012 | 1356397-46-0 | 5-(4-chlorophenyl)-3-iodopyridin-2-amine |
| VEMF-013 | 1360111-87-0 | (E)-2-(2-ethoxyvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane |
| VEMF-014 | 918516-27-5 | 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine |
| VEMF-015 | 911113-60-5 | 3-bromo-5-(4-chlorophenyl)pyridin-2-amine |
| VEMF-016 | 1066-54-2 | ethynyltrimethylsilane |
| VEMF-017 | 1356397-48-2 | 5-(4-chlorophenyl)-3-((trimethylsilyl)ethynyl)pyridin-2-amine |
OptimisedRoute 3Steps 6 · Total yield 49 g
| Code | CAS No. | Intermediate |
|---|---|---|
| VEMF-005 | 1103234-56-5 | 2,6-difluoro-3-(propylsulfonamido)benzoic acid |
| VEMF-007 | 183208-35-7Available | 5-bromo-1H-pyrrolo[2,3-b]pyridine |
| VEMF-008 | 918504-27-5 | N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide |
| VEMF-009 | 1679-18-1Available | (4-chlorophenyl)boronic acid |
| VEMF-010 | 1072-97-5 | 5-bromopyridin-2-amine |
| VEMF-013 | 1360111-87-0 | (E)-2-(2-ethoxyvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane |
| VEMF-018 | 381233-96-1 | 5-bromo-3-iodopyridin-2-amine |
| VEMF-019 | 4659-45-4 | 2,6-dichlorobenzoyl chloride |
| VEMF-020 | 1262985-24-9 | N-(3-(5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide |
| VEMF-021 | 1262985-23-8 | N-(3-(5-(4-chlorophenyl)-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide |
OptimisedRoute 4Steps 6 · Total yield 763 g
| Code | CAS No. | Intermediate |
|---|---|---|
| VEMF-003 | 10147-36-1 | propane-1-sulfonyl chloride |
| VEMF-007 | 183208-35-7Available | 5-bromo-1H-pyrrolo[2,3-b]pyridine |
| VEMF-009 | 1679-18-1Available | (4-chlorophenyl)boronic acid |
| VEMF-019 | 4659-45-4 | 2,6-dichlorobenzoyl chloride |
| VEMF-021 | 1262985-23-8 | N-(3-(5-(4-chlorophenyl)-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide |
| VEMF-022 | 260552-98-5 | 2,6-difluoro-3-nitrobenzoyl chloride |
| VEMF-023 | 918520-16-8 | (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2,6-difluoro-3-nitrophenyl)methanone |
| VEMF-024 | 1312941-98-2 | (3-amino-2,6-difluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone |
| VEMF-025 | 1501153-67-8 | (3-(3-amino-2,6-difluorobenzoyl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl)(2,6-dichlorophenyl)methanone |
| VEMF-026 | 1501153-68-9 | (3-(3-amino-2,6-difluorobenzoyl)-5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)(2,6-dichlorophenyl)methanone |
OptimisedRoute 5Steps 4 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| VEMF-001 | 367-25-9 | 2,4-difluoroaniline |
| VEMF-003 | 10147-36-1 | propane-1-sulfonyl chloride |
| VEMF-014 | 918516-27-5 | 5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine |
| VEMF-027 | 918523-57-6 | N-(2,4-difluorophenyl)propane-1-sulfonamide |
| VEMF-028 | 4394-85-8 | morpholine-4-carbaldehyde |
| VEMF-029 | 918523-58-7 | N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide |
| VEMF-030 | 1227958-55-5 | N-(3-((5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)(hydroxy)methyl)-2,4-difluorophenyl)propane-1-sulfonamide |
Frequently asked questions
What are the approved indications of Vemurafenib?
Approved indications include: Erdheim-Chester病, 黑色素瘤.
When does the Vemurafenib patent expire?
No public expiry year is available for Vemurafenib yet; this page updates once verified.
How many synthesis routes are recorded for Vemurafenib?
5 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Vemurafenib intermediates?
2 intermediate CAS of Vemurafenib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Vemurafenib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24