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CAS 442514-54-7
(3S,4S,5R)-5-fluoro-6-hydroxytetrahydro-2H-pyran-3,4-diyl diacetate
Codes：CLEVU-014
Application context (from source-drug indications)
乙型肝炎克拉夫定新型冠状病毒感染克拉夫定
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 克拉夫定Clevudine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
((2S,3S,4R,5S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydrofuran-2-yl)methyl benzoate→((2S,3S,4R,5S)-3-(benzoyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl benzoate→(3R,4S,5S)-tetrahydro-2H-pyran-2,3,4,5-tetraol→(3R,4S,5S)-tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate→(2R,3R,4S,5S)-2-bromotetrahydro-2H-pyran-3,4,5-triyl triacetate→(3S,4R)-3,4-dihydro-2H-pyran-3,4-diyl diacetate→(3S,4S,5R)-5-fluoro-6-hydroxytetrahydro-2H-pyran-3,4-diyl diacetate→(3R,4S,5S)-3-fluorotetrahydro-2H-pyran-2,4,5-triol→(2S,3S,4R)-4-fluoro-2-(hydroxymethyl)-5-methoxytetrahydrofuran-3-ol→((2S,3S,4R,5R)-3-(benzoyloxy)-4-fluoro-5-methoxytetrahydrofuran-2-yl)methyl benzoate→5-methyl-2,4-bis((trimethylsilyl)oxy)pyrimidine
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