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CAS 463-78-5

methanetriol

Codes:DECI-004

Application context (from source-drug indications)

过敏反应地西他滨睫状肌麻痹地西他滨低血压地西他滨急性髓细胞样白血病地西他滨骨髓增生异常综合征地西他滨弥漫性大B-细胞淋巴瘤地西他滨

Source drugs (routes using this intermediate)

DrugTierExpiry
地西他滨DecitabineTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

地西他滨原研路线steps: 3total yield: 1.65 g
((2R,3S)-3-acetoxy-5-isocyanatotetrahydrofuran-2-yl)methyl acetate→methyl carbamimidothioate→((2R,3S)-3-acetoxy-5-(3-((E)-amino(methylthio)methylene)ureido)tetrahydrofuran-2-yl)methyl acetate→methanetriol→((2R,3S,5R)-3-acetoxy-5-(4-(methylthio)-2-oxo-1,3,5-triazin-1(2H)-yl)tetrahydrofuran-2-yl)methyl acetate

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