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CAS 503614-91-3
ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Codes：APIX-009
Application context (from source-drug indications)
肺栓塞阿哌沙班静脉血栓形成阿哌沙班Paget-Schroetter综合征阿哌沙班静脉血栓栓塞阿哌沙班血栓形成阿哌沙班栓塞阿哌沙班
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 阿哌沙班Apixaban | Tier A — Act now | 2028 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-iodoaniline→5-bromopentanoyl chloride→1-(4-iodophenyl)piperidin-2-one→3,3-dichloro-1-(4-iodophenyl)piperidin-2-one→1-(4-iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one→ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate→ethyl 6-(4-iodophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→piperidin-2-one→ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
4-iodoaniline→1-(4-iodophenyl)piperidin-2-one→3,3-dichloro-1-(4-iodophenyl)piperidin-2-one→1-(4-iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one→ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate→piperidin-2-one→ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→morpholine→5-bromopentanoic acid→5-bromo-N-(4-iodophenyl)pentanamide→3-chloro-1-(4-iodophenyl)-5,6-dihydropyridin-2(1H)-one→3-morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate→ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→4-nitroaniline→5-chloropentanoyl chloride→5-bromopentanoyl chloride→1-(4-nitrophenyl)piperidin-2-one→3,3-dichloro-1-(4-nitrophenyl)piperidin-2-one→3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one→ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→ethyl 6-(4-aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→ethyl 6-(4-(5-chloropentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→ethyl 6-(4-(5-bromopentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate→ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→3-morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one→4-nitroaniline→1-(4-nitrophenyl)piperidin-2-one→5-chloropentanoyl chloride→3-morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one→1-(4-aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one
ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate→ethyl 6-(4-iodophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→piperidin-2-one→ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→1-(4-iodophenyl)piperidine-2,3-dione→1-(4-iodophenyl)-3-((trimethylsilyl)oxy)-5,6-dihydropyridin-2(1H)-one→1-(4-iodophenyl)-2-oxo-1,2,5,6-tetrahydropyridin-3-yl 4-methylbenzenesulfonate
Intermediates available on this site
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| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 1-(4-Methoxyphenyl)-7-0xo-6-[4-(2-0xopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acidethyl ester Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
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