CAS 504-24-5

pyridin-4-amine

Codes：EDOX-015、AMIF-005

Application context (from source-drug indications)

肺栓塞甲苯磺酸艾多沙班静脉血栓栓塞甲苯磺酸艾多沙班中风甲苯磺酸艾多沙班栓塞甲苯磺酸艾多沙班静脉血栓形成甲苯磺酸艾多沙班缺血性卒中甲苯磺酸艾多沙班郎伯综合征磷酸阿米吡啶脊髓性肌萎缩磷酸阿米吡啶重症肌无力磷酸阿米吡啶小儿脊髓性肌萎缩磷酸阿米吡啶先天性肌无力综合征磷酸阿米吡啶多发性硬化磷酸阿米吡啶

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
甲苯磺酸艾多沙班Edoxaban Tosilate Hydrate	Tier B — Position early	2028
磷酸阿米吡啶Amifampridine Phosphate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

甲苯磺酸艾多沙班优化路线steps: 5total yield: /

lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate→pyridin-4-amine→tert-butyl pyridin-4-ylcarbamate→tert-butyl (3-mercaptopyridin-4-yl)carbamate→thiazolo[5,4-c]pyridine→5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

磷酸阿米吡啶优化路线steps: 4total yield: 535 mg

3-nitropyridin-4-amine→pyridin-4-amine→N-(3-nitropyridin-4-yl)acetamide→N-(pyridin-4-yl)acetamide

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