CAS 50704-42-2

(Z)-2-chloro-3-hydroxyacrylaldehyde

Codes: ETOR-021

Application context (from source-drug indications)

OsteoarthritisEtoricoxib痛风性关节炎EtoricoxibDysmenorrhoeaEtoricoxibRheumatoid arthritisEtoricoxibAnkylosing spondylitisEtoricoxibParkinson's diseaseEtoricoxib

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Etoricoxib	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

EtoricoxibOptimised routesteps: 3total yield: /

N-methoxy-N,6-dimethylnicotinamide→1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethan-1-one→(4-(chloromethyl)phenyl)(methyl)sulfane→1-(6-methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethan-1-one→(Z)-2-chloro-3-hydroxyacrylaldehyde

EtoricoxibOptimised routesteps: 1total yield: 1.81 g

1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethan-1-one→(Z)-2-chloro-3-hydroxyacrylaldehyde

Intermediates available on this site

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