← Back to patent-cliff list
CAS 221615-75-4
1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethan-1-one
Codes: ETOR-014
Application context (from source-drug indications)
OsteoarthritisEtoricoxib痛风性关节炎EtoricoxibDysmenorrhoeaEtoricoxibRheumatoid arthritisEtoricoxibAnkylosing spondylitisEtoricoxibParkinson's diseaseEtoricoxib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Etoricoxib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl 6-methylnicotinate→N-methoxy-N,6-dimethylnicotinamide→6-methylnicotinaldehyde→diphenyl ((6-methylpyridin-3-yl)(phenylamino)methyl)phosphonate→4-(methylsulfonyl)benzaldehyde→(E)-N-(1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)vinyl)aniline→1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethan-1-one→ETOR-015→(Z)-4-chloro-3,5-bis(dimethylamino)-1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)pent-4-en-1-one→(2Z,4Z)-4-chloro-5-(dimethylamino)-1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)penta-2,4-dien-1-one
N-methoxy-N,6-dimethylnicotinamide→1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethan-1-one→(4-(chloromethyl)phenyl)(methyl)sulfane→1-(6-methylpyridin-3-yl)-2-(4-(methylthio)phenyl)ethan-1-one→(Z)-2-chloro-3-hydroxyacrylaldehyde
1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethan-1-one→methyl (E)-2-chloro-3-(tosyloxy)acrylate→3-chloro-6-(6-methylpyridin-3-yl)-5-(4-(methylsulfonyl)phenyl)-2H-pyran-2-one→5-chloro-6'-methyl-3-(4-(methylsulfonyl)phenyl)-[2,3'-bipyridin]-6-ol→5-chloro-6'-methyl-3-(4-(methylsulfonyl)phenyl)-[2,3'-bipyridin]-6-yl 4-methylbenzenesulfonate
1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethan-1-one→(Z)-2-chloro-3-hydroxyacrylaldehyde
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.