CAS 538-75-0

dicyclohexylmethanediimine

Codes：DAPR-001

Application context (from source-drug indications)

贫血达普司他

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
达普司他Daprodustat	Tier C — Watch / trade	2032

Position in synthesis routes (up/downstream chain)

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达普司他原研路线steps: 3total yield: 116.2 g

dicyclohexylmethanediimine→malonic acid→1,3-dicyclohexylpyrimidine-2,4,6(1H,3H,5H)-trione→ethyl 2-isocyanatoacetate→ethyl (1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycinate

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