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CAS 5460-29-7
2-(3-bromopropyl)isoindoline-1,3-dione
Codes：IVAB-015
Application context (from source-drug indications)
心脏衰竭盐酸伊伐布雷定心绞痛盐酸伊伐布雷定心源性休克盐酸伊伐布雷定缺血性心脏病盐酸伊伐布雷定稳定型心绞痛盐酸伊伐布雷定淋巴瘤盐酸伊伐布雷定
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 盐酸伊伐布雷定Ivabradine Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)-N-methylmethanamine→(S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one→2-(3-bromopropyl)isoindoline-1,3-dione→(S)-2-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)isoindoline-1,3-dione→(S)-N1-((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N1-methylpropane-1,3-diamine→2,2-dimethoxyacetaldehyde→(S)-N1-((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N3-(2,2-dimethoxyethyl)-N1-methylpropane-1,3-diamine→2-(3,4-dimethoxyphenyl)acetyl chloride→(S)-N-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl)acetamide
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