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盐酸伊伐布雷定

Tier C — Watch / trade

Ivabradine Hydrochloride

法国施维雅药厂
Originator
2005
First approval
-
Expiry (public)
No sales data
Peak sales
化学药
Type

Targets：HCN channels

Brand：Coralan、Coraxan、Procoralan、Corlentor、Corlanor、可兰特

Indications (approved)：心脏衰竭、心绞痛

Regional status

US
撤市
EU
批准上市
2005-10-25
China
批准上市
2015-04-29
Japan
批准上市
2019-09-20

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield 0.5 g
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
IVAB-00135202-54-13,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-triene-7-carbonitrile
IVAB-00273344-75-9(3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methanamine
IVAB-003148870-55-71-(3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)-N-methylmethanamine
IVAB-004148870-55-71-(3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)-N-methylmethanamine
IVAB-005866783-12-2(S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamine
IVAB-006148870-57-93-(3-iodopropyl)-7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one
IVAB-0071086026-31-4(S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one
IVAB-008155974-00-8(S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one
OptimisedRoute 2Steps 4 · Total yield 0.95 g
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
IVAB-008155974-00-8(S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one
IVAB-00973942-87-77,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one
IVAB-0101069115-30-5tert-butyl (3-chloropropyl)(methyl)carbamate
IVAB-0111069115-32-7tert-butyl (3-(7,8-dimethoxy-2-oxo-1H-benzo[d]azepin-3(2H)-yl)propyl)(methyl)carbamate
IVAB-012163629-94-57,8-dimethoxy-3-(3-(methylamino)propyl)-1H-benzo[d]azepin-2(3H)-one
IVAB-0131206230-27-47-(iodomethyl)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-triene
IVAB-014148870-58-03-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one
OptimisedRoute 3Steps 5 · Total yield 270 mg
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
IVAB-004148870-55-71-(3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)-N-methylmethanamine
IVAB-008155974-00-8(S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one
IVAB-0155460-29-72-(3-bromopropyl)isoindoline-1,3-dione
IVAB-0161393427-01-4(S)-2-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)isoindoline-1,3-dione
IVAB-0171393427-02-5(S)-N1-((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N1-methylpropane-1,3-diamine
IVAB-01851673-84-82,2-dimethoxyacetaldehyde
IVAB-0191393427-03-6(S)-N1-((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N3-(2,2-dimethoxyethyl)-N1-methylpropane-1,3-diamine
IVAB-02010313-60-72-(3,4-dimethoxyphenyl)acetyl chloride
IVAB-0211393427-04-7(S)-N-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl)acetamide
OptimisedRoute 4Steps 5 · Total yield /
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
IVAB-00973942-87-77,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one
IVAB-02237895-73-13-bromopropanenitrile
IVAB-0232678-54-83-(7,8-dimethoxy-2-oxo-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)propanenitrile
IVAB-0241132079-01-6(S)-(3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methanamine hydrochloride
IVAB-0251246638-10-7(S)-3-(7,8-dimethoxy-2-oxo-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-N-((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)propanimidamide
IVAB-026215935-23-2(S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one
IVAB-0271246672-58-1(S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one hydrochloride
OptimisedRoute 5Steps 8 · Total yield 600 mg
Synthetic routes & intermediates Route 5
CodeCAS No.Intermediate
IVAB-028120-20-7Available2-(3,4-dimethoxyphenyl)ethanamine
IVAB-02998062-25-0tert-butyl (3,4-dimethoxyphenethyl)carbamate
IVAB-0301031767-71-1(S)-3-chloro-N-((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N-methylpropan-1-amine
IVAB-0311325209-22-0tert-butyl (S)-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)(3,4-dimethoxyphenethyl)carbamate
IVAB-0321325209-23-1(S)-N1-((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N3-(3,4-dimethoxyphenethyl)-N1-methylpropane-1,3-diamine
IVAB-0331325209-25-3(S)-2-((3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)(3,4-dimethoxyphenethyl)amino)-2-oxoethyl acetate
IVAB-0341325209-24-2(S)-N-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-N-(3,4-dimethoxyphenethyl)-2-hydroxyacetamide
IVAB-0351325209-26-4(S)-N-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-N-(3,4-dimethoxyphenethyl)-2-oxoacetamide
IVAB-0361325209-27-53-(3-((((S)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1-(phenylthio)-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one

Frequently asked questions

What are the approved indications of Ivabradine Hydrochloride?

Approved indications include: 心脏衰竭, 心绞痛.

When does the Ivabradine Hydrochloride patent expire?

No public expiry year is available for Ivabradine Hydrochloride yet; this page updates once verified.

How many synthesis routes are recorded for Ivabradine Hydrochloride?

5 synthesis routes are recorded; the shortest is 4 steps with 0.95 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ivabradine Hydrochloride intermediates?

1 intermediate CAS of Ivabradine Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Ivabradine Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24